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https://hdl.handle.net/10356/155071| Title: | Carbene-catalyzed atroposelective annulation and desymmetrization of urazoles | Authors: | Jin, Jiamiao Huang, Xuan Xu, Jun Li, Tingting Peng, Xiaolin Zhu, Xun Zhang, Junmin Jin, Zhichao Chi, Robin Yonggui |
Keywords: | Science::Chemistry | Issue Date: | 2021 | Source: | Jin, J., Huang, X., Xu, J., Li, T., Peng, X., Zhu, X., Zhang, J., Jin, Z. & Chi, R. Y. (2021). Carbene-catalyzed atroposelective annulation and desymmetrization of urazoles. Organic Letters, 23(10), 3991-3996. https://dx.doi.org/10.1021/acs.orglett.1c01191 | Project: | NRF-NRFI2016-06 RG108/16 RG5/19 RG1/18 MOE2018-T3-1-003 A1783c0008 A1783c0010 |
Journal: | Organic Letters | Abstract: | An NHC-catalyzed atroposelective reaction between ynals and urazoles is disclosed. The reaction establishes a chiral C-N axis via an atroposelective [3 + 2] annulation/desymmetrization process. Our reaction allows efficient access to axially chiral and heteroatom-rich urazole derivatives with potential applications in bioactive molecules and catalysis. | URI: | https://hdl.handle.net/10356/155071 | ISSN: | 1523-7060 | DOI: | 10.1021/acs.orglett.1c01191 | Rights: | © 2021 American Chemical Society. All rights reserved. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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