Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155074
Title: Self-assembly of solubilized human hair keratins
Authors: Lai, Hui Ying
Setyawati, Magdiel Inggrid
Abdul Rahim Ferhan
Divakarla, Shiva Kamini
Chua, Huei Min
Cho, Nam-Joon
Chrzanowski, Wojciech
Ng, Kee Woei
Keywords: Engineering::Materials::Biomaterials
Issue Date: 2021
Source: Lai, H. Y., Setyawati, M. I., Abdul Rahim Ferhan, Divakarla, S. K., Chua, H. M., Cho, N., Chrzanowski, W. & Ng, K. W. (2021). Self-assembly of solubilized human hair keratins. ACS Biomaterials Science & Engineering, 7(1), 83-89. https://dx.doi.org/10.1021/acsbiomaterials.0c01507
Project: H17/01/a0/008
H17/01/a0/0L9
Journal: ACS Biomaterials Science & Engineering
Abstract: Human hair keratins have proven to be a viable biomaterial for diverse regenerative applications. However, the most significant characteristic of this material, the ability to self-assemble into nanoscale intermediate filaments, has not been exploited. Herein, we successfully demonstrated the induction of hair-extracted keratin self-assembly in vitro to form dense, homogeneous, and continuous nanofibrous networks. These networks remain hydrolytically stable in vitro for up to 5 days in complete cell culture media and are compatible with primary human dermal fibroblasts and keratinocytes. These results enhance the versatility of human hair keratins for applications where structured assembly is of benefit.
URI: https://hdl.handle.net/10356/155074
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.0c01507
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Biomaterials Science & Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsbiomaterials.0c01507.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles
NEWRI Journal Articles

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