Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155084
Title: Asymmetric three-component Heck arylation/amination of nonconjugated cyclodienes
Authors: Zhu, Daoyong
Jiao, Zhiwei
Chi, Robin Yonggui
Gonçalves, Théo P.
Huang, Kuo-Wei
Zhou, Steve Jianrong
Keywords: Science::Chemistry
Issue Date: 2020
Source: Zhu, D., Jiao, Z., Chi, R. Y., Gonçalves, T. P., Huang, K. & Zhou, S. J. (2020). Asymmetric three-component Heck arylation/amination of nonconjugated cyclodienes. Angewandte Chemie International Edition, 59(13), 5341-5345. https://dx.doi.org/10.1002/anie.201915864
Project: AME IRG A1783c0010
Journal: Angewandte Chemie International Edition
Abstract: Substituted cyclohexylamines are becoming increasingly important in drug discovery. Asymmetric Heck insertion/amination of nonconjugated cyclodienes proceeds to give 5-aryl cyclohexenylamines with good enantioselectivity and exclusive trans configurations. Primary and secondary anilines, indoline, and benzylamines are suitable amines. The weakly donating diphosphite Kelliphite forms a deep unsymmetrical pocket, which is essential for stereoselective anti attack of amines.
URI: https://hdl.handle.net/10356/155084
ISSN: 1433-7851
DOI: 10.1002/anie.201915864
Rights: This is the peer reviewed version of the following article: Zhu, D., Jiao, Z., Chi, R. Y., Gonçalves, T. P., Huang, K. & Zhou, S. J. (2020). Asymmetric three-component Heck arylation/amination of nonconjugated cyclodienes. Angewandte Chemie International Edition, 59(13), 5341-5345, which has been published in final form at https://doi.org/10.1002/anie.201915864. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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