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https://hdl.handle.net/10356/155084| Title: | Asymmetric three-component Heck arylation/amination of nonconjugated cyclodienes | Authors: | Zhu, Daoyong Jiao, Zhiwei Chi, Robin Yonggui Gonçalves, Théo P. Huang, Kuo-Wei Zhou, Steve Jianrong |
Keywords: | Science::Chemistry | Issue Date: | 2020 | Source: | Zhu, D., Jiao, Z., Chi, R. Y., Gonçalves, T. P., Huang, K. & Zhou, S. J. (2020). Asymmetric three-component Heck arylation/amination of nonconjugated cyclodienes. Angewandte Chemie International Edition, 59(13), 5341-5345. https://dx.doi.org/10.1002/anie.201915864 | Project: | AME IRG A1783c0010 | Journal: | Angewandte Chemie International Edition | Abstract: | Substituted cyclohexylamines are becoming increasingly important in drug discovery. Asymmetric Heck insertion/amination of nonconjugated cyclodienes proceeds to give 5-aryl cyclohexenylamines with good enantioselectivity and exclusive trans configurations. Primary and secondary anilines, indoline, and benzylamines are suitable amines. The weakly donating diphosphite Kelliphite forms a deep unsymmetrical pocket, which is essential for stereoselective anti attack of amines. | URI: | https://hdl.handle.net/10356/155084 | ISSN: | 1433-7851 | DOI: | 10.1002/anie.201915864 | Rights: | This is the peer reviewed version of the following article: Zhu, D., Jiao, Z., Chi, R. Y., Gonçalves, T. P., Huang, K. & Zhou, S. J. (2020). Asymmetric three-component Heck arylation/amination of nonconjugated cyclodienes. Angewandte Chemie International Edition, 59(13), 5341-5345, which has been published in final form at https://doi.org/10.1002/anie.201915864. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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| Angewandte Chemie Intl Edit - 2020 - Zhu - Asymmetric Three%u2010Component Heck Arylation Amination of Nonconjugated Cyclodienes.pdf | 661.36 kB | Adobe PDF | View/Open |
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