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https://hdl.handle.net/10356/155086| Title: | Asymmetric reductive and alkynylative heck bicyclization of enynes to access conformationally restricted aza[3.1.0]bicycles | Authors: | Huang, Xiaolei Nguyen, Minh Hieu Pu, Maoping Zhang, Luoqiang Chi, Robin Yonggui Wu, Yun-Dong Zhou, Steve Jianrong |
Keywords: | Science::Chemistry | Issue Date: | 2020 | Source: | Huang, X., Nguyen, M. H., Pu, M., Zhang, L., Chi, R. Y., Wu, Y. & Zhou, S. J. (2020). Asymmetric reductive and alkynylative heck bicyclization of enynes to access conformationally restricted aza[3.1.0]bicycles. Angewandte Chemie International Edition, 59(27), 10814-10818. https://dx.doi.org/10.1002/anie.202000859 | Project: | AME IRG A1783c0010 | Journal: | Angewandte Chemie International Edition | Abstract: | Conformationally restricted azabicycles are becoming increasingly important in medicinal research. Asymmetric Heck bicyclization of enynes proceeds to give medicinally useful aza[3.1.0] and aza[4.1.0] bicycles with excellent enantioselectivity. The key organopalladium species after bicyclization can be trapped by silanes and terminal alkynes. | URI: | https://hdl.handle.net/10356/155086 | ISSN: | 1521-3773 | DOI: | 10.1002/anie.202000859 | Schools: | School of Physical and Mathematical Sciences | Rights: | This is the peer reviewed version of the following article: Huang, X., Nguyen, M. H., Pu, M., Zhang, L., Chi, R. Y., Wu, Y. & Zhou, S. J. (2020). Asymmetric reductive and alkynylative heck bicyclization of enynes to access conformationally restricted aza[3.1.0]bicycles. Angewandte Chemie International Edition, 59(27), 10814-10818, which has been published in final form at https://doi.org/10.1002/anie.202000859. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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| Angewandte Chemie Intl Edit - 2020 - Huang - Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access.pdf | 627.86 kB | Adobe PDF |  View/Open |
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