Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155086
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dc.contributor.authorHuang, Xiaoleien_US
dc.contributor.authorNguyen, Minh Hieuen_US
dc.contributor.authorPu, Maopingen_US
dc.contributor.authorZhang, Luoqiangen_US
dc.contributor.authorChi, Robin Yongguien_US
dc.contributor.authorWu, Yun-Dongen_US
dc.contributor.authorZhou, Steve Jianrongen_US
dc.date.accessioned2022-02-09T01:45:54Z-
dc.date.available2022-02-09T01:45:54Z-
dc.date.issued2020-
dc.identifier.citationHuang, X., Nguyen, M. H., Pu, M., Zhang, L., Chi, R. Y., Wu, Y. & Zhou, S. J. (2020). Asymmetric reductive and alkynylative heck bicyclization of enynes to access conformationally restricted aza[3.1.0]bicycles. Angewandte Chemie International Edition, 59(27), 10814-10818. https://dx.doi.org/10.1002/anie.202000859en_US
dc.identifier.issn1521-3773en_US
dc.identifier.urihttps://hdl.handle.net/10356/155086-
dc.description.abstractConformationally restricted azabicycles are becoming increasingly important in medicinal research. Asymmetric Heck bicyclization of enynes proceeds to give medicinally useful aza[3.1.0] and aza[4.1.0] bicycles with excellent enantioselectivity. The key organopalladium species after bicyclization can be trapped by silanes and terminal alkynes.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipEconomic Development Board (EDB)en_US
dc.language.isoenen_US
dc.relationAME IRG A1783c0010en_US
dc.relation.ispartofAngewandte Chemie International Editionen_US
dc.rightsThis is the peer reviewed version of the following article: Huang, X., Nguyen, M. H., Pu, M., Zhang, L., Chi, R. Y., Wu, Y. & Zhou, S. J. (2020). Asymmetric reductive and alkynylative heck bicyclization of enynes to access conformationally restricted aza[3.1.0]bicycles. Angewandte Chemie International Edition, 59(27), 10814-10818, which has been published in final form at https://doi.org/10.1002/anie.202000859. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectScience::Chemistryen_US
dc.titleAsymmetric reductive and alkynylative heck bicyclization of enynes to access conformationally restricted aza[3.1.0]bicyclesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1002/anie.202000859-
dc.description.versionAccepted versionen_US
dc.identifier.pmid32219962-
dc.identifier.scopus2-s2.0-85085926507-
dc.identifier.issue27en_US
dc.identifier.volume59en_US
dc.identifier.spage10814en_US
dc.identifier.epage10818en_US
dc.subject.keywordsAlkynylationen_US
dc.subject.keywordsAzabicyclesen_US
dc.description.acknowledgementWe acknowledge financial support from Peking UniversityShenzhen Graduate School, Shenzhen Bay Laboratory(21230011-Scripps), National Natural Science Foundation ofChina (NSFC 21933004), Nanyang Technological University,GSK-EDB Trust Fund (2017 GSK-EDB Green and Sustain-able Manufacturing Award) and A*STAR Science andEngineering Research Council (AME IRG A1783c0010).MP contributed DFT calculations.en_US
item.grantfulltextopen-
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