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Title: Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice
Authors: Chen, Qi
Lai, Si Min
Xu, Shaohai
Tan, Yingrou
Leong, Keith
Liu, Dehua
Tan, Jia Chi
Naik, Roshan Ratnakar
Barron, Anna M.
Adav, Sunil S.
Chen, Jinmiao
Chong, Shu Zhen
Ng, Lai Guan
Ruedl, Christiane
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Chen, Q., Lai, S. M., Xu, S., Tan, Y., Leong, K., Liu, D., Tan, J. C., Naik, R. R., Barron, A. M., Adav, S. S., Chen, J., Chong, S. Z., Ng, L. G. & Ruedl, C. (2021). Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice. EMBO Reports, 22(8), e52835-.
Project: MOE2018-T2-2-016
Journal: EMBO reports
Abstract: Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to the metabolic changes of their microenvironment that are often induced by excess energy intake. Currently, the exact contribution of these macrophages in obesity-driven WAT remodeling remains controversial. Here, using a transgenic CD169-DTR mouse strain, we provide new insights into the interplay between CD169+ adipose tissue macrophages (ATMs) and their surrounding WAT microenvironment. Using targeted in vivo ATM ablation followed by transcriptional and metabolic WAT profiling, we found that ATMs protect WAT from the excessive pathological remodeling that occurs during obesity. As obesity progresses, ATMs control not only vascular integrity, adipocyte function, and lipid and metabolic derangements but also extracellular matrix accumulation and resultant fibrosis in the WAT. The protective role of ATMs during obesity-driven WAT dysfunction supports the notion that ATMs represent friends, rather than foes, as has previously assumed.
ISSN: 1469-221X
DOI: 10.15252/embr.202152835
DOI (Related Dataset): 10.21979/N9/9J9BWD
Rights: © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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