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Title: Extraspecific manifestation of nanoheater's position effect on distinctive cellular photothermal responses
Authors: Cong, Thang Do
Wang, Zhimin
Hu, Ming
Han, Qinyu
Xing, Bengang
Keywords: Science::Chemistry::Biochemistry
Issue Date: 2020
Source: Cong, T. D., Wang, Z., Hu, M., Han, Q. & Xing, B. (2020). Extraspecific manifestation of nanoheater's position effect on distinctive cellular photothermal responses. ACS Nano, 14(5), 5836-5844.
Project: MOE 2017-T2-2-110
Tier 1 RG5/18 (S)
Journal: ACS nano
Abstract: Subcellular localization of nanoparticles plays critical roles in precision medicine that can facilitate an in-depth understanding of disease etiology and achieve accurate theranostic regulation via responding to the aiding stimuli. The photothermal effect is an extensively employed strategy that converts light into heat stimulation to induce localized disease ablation. Despite diverse manipulations that have been investigated in photothermal nanotheranostics, influences of nanoheaters' subcellular distribution and their molecular mechanism on cellular heat response remain elusive. Herein, we disclose the biological basis of distinguishable thermal effects at subcellular resolution by localizing photothermal upconversion nanoparticles into specific locations of cell compartments. Upon 808 nm light excitation, the lysosomal cellular uptake initialized by poly(ethylenimine)-modified nanoheaters promoted mitochondria apoptosis through the activation of Bid protein, whereas the cell surface nanoheaters anchored via metabolic glycol biosynthesis triggered necrosis by direct perturbation of the membrane structure. Intriguingly, these two different thermolyses revealed similar levels of heat shock protein expression in live cells. This study stipulates insights underlying the different subcellular positions of nanoparticles for the selective thermal response, which provides valuable perspectives on optimal precision nanomedicine.
ISSN: 1936-0851
DOI: 10.1021/acsnano.0c00951
Schools: School of Physical and Mathematical Sciences 
Rights: © 2020 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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