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dc.contributor.authorKoh, Kenricken_US
dc.contributor.authorWang, Jun Kiten_US
dc.contributor.authorGabryelczyk, Bartoszen_US
dc.contributor.authorTay, Daltonen_US
dc.contributor.authorTan, Nguan Soonen_US
dc.contributor.authorMiserez, Alien_US
dc.identifier.citationKoh, K., Wang, J. K., Gabryelczyk, B., Tay, D., Tan, N. S. & Miserez, A. (2022). Squid suckerin-spider silk fusion protein hydrogel for stem cell-secretome delivery in chronic wounds. 2022 MRS Spring Meeting & Exhibit.en_US
dc.description.abstractThe squid sucker ring teeth, used in tandem with the suckers on the squid’s tentacles to capture prey, is comprised of mainly suckerin, a protein material. Squid suckerin is a promising biopolymer for wound dressings due to its biocompatibility, antibacterial properties, and its ability to form gels/films of varying mechanical properties. However, issues such as low recombinant solubility and the requirement of harsh photochemical means for gel/film formation hinders suckerin’s suitability for encapsulation and delivery of stem cell-secretome, which is a bioactive yet sensitive therapeutic shown to overcome persistent wound inflammation and accelerate wound healing. Via bioinspired design, we developed a novel squid suckerin-spider silk fusion protein hydrogel, where the fusion of key spider silk sequences conferred high solubility and heat-induced gelation properties that enabled encapsulation of secretome without denaturation. The protein hydrogel is capable of long-term delivery of secretome via protein-protein interaction. Additionally, due to its modular design, we incorporated cell adhesion peptides to promote biocompatibility of the hydrogel. In our results, we demonstrate the secretome-loaded hydrogel potential for clinical use via accelerated healing of excisional chronic wounds in vivo.en_US
dc.rights© 2022 Materials Research Society. All rights reserved.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleSquid suckerin-spider silk fusion protein hydrogel for stem cell-secretome delivery in chronic woundsen_US
dc.typeConference Paperen
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.contributor.conference2022 MRS Spring Meeting & Exhibiten_US
dc.subject.keywordsSquid Suckerinen_US
dc.subject.keywordsProtein Hydrogelen_US
dc.citation.conferencelocationHonolulu, Hawaiien_US
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