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Title: Reciprocal-activation strategy for allylic sulfination with unactivated allylic alcohols
Authors: Xie, Peizhong
Sun, Zuolian
Li, Shuangshuang
Cai, Xinying
Qiu, Ju
Fu, Weishan
Gao, Cuiqing
Wu, Shisheng
Yang, Xiaobo
Loh, Teck-Peng
Keywords: Science::Chemistry
Issue Date: 2020
Source: Xie, P., Sun, Z., Li, S., Cai, X., Qiu, J., Fu, W., Gao, C., Wu, S., Yang, X. & Loh, T. (2020). Reciprocal-activation strategy for allylic sulfination with unactivated allylic alcohols. Organic Letters, 22(12), 4893-4897.
Project: 2016-T1-002-043
Journal: Organic Letters
Abstract: A reciprocal-activation strategy for allylic sulfination with unactivated allylic alcohols was developed. In this reaction, the hydrogen bond interaction between allylic alcohols and sulfinic acids allowed for reciprocal activation, which enabled a dehydrative cross-coupling process to occur under mild reaction conditions. This reaction worked in an environmentally friendly manner, yielding water as the only byproduct. A variety of allylic sulfones could be obtained in good to excellent yields with wide functional group tolerance. In gram scale reactions, allylic sulfones could be conveniently isolated in high yield by filtration.
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.0c01747
Rights: © 2020 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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