Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155332
Title: 2H-azirines as potential bifunctional chemical linkers of cysteine residues in bioconjugate technology
Authors: Chen, Yang
Yang, Wenjie
Wu, Jiamin
Sun, Wangbin
Loh, Teck-Peng
Jiang, Yaojia
Keywords: Science::Chemistry
Issue Date: 2020
Source: Chen, Y., Yang, W., Wu, J., Sun, W., Loh, T. & Jiang, Y. (2020). 2H-azirines as potential bifunctional chemical linkers of cysteine residues in bioconjugate technology. Organic Letters, 22(5), 2038-2043. https://dx.doi.org/10.1021/acs.orglett.0c00415
Journal: Organic Letters
Abstract: 2H-Azirine-2-caboxamides have been designed to perform as a new type of bifunctional thiol linker under very mild reaction conditions. The cleavage of a C-N double bond of 2H-azirine furnishes an amino amide functional group in situ through a thiol addition and ring-opening process. It works with a broad scope of thiols and 2H-azirines in the absence of any catalysts at room temperature. Cysteine-containing peptides have also been demonstrated to work efficiently in a completely water solution.
URI: https://hdl.handle.net/10356/155332
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.0c00415
Rights: © 2020 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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