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|Title:||2H-azirines as potential bifunctional chemical linkers of cysteine residues in bioconjugate technology||Authors:||Chen, Yang
|Keywords:||Science::Chemistry||Issue Date:||2020||Source:||Chen, Y., Yang, W., Wu, J., Sun, W., Loh, T. & Jiang, Y. (2020). 2H-azirines as potential bifunctional chemical linkers of cysteine residues in bioconjugate technology. Organic Letters, 22(5), 2038-2043. https://dx.doi.org/10.1021/acs.orglett.0c00415||Journal:||Organic Letters||Abstract:||2H-Azirine-2-caboxamides have been designed to perform as a new type of bifunctional thiol linker under very mild reaction conditions. The cleavage of a C-N double bond of 2H-azirine furnishes an amino amide functional group in situ through a thiol addition and ring-opening process. It works with a broad scope of thiols and 2H-azirines in the absence of any catalysts at room temperature. Cysteine-containing peptides have also been demonstrated to work efficiently in a completely water solution.||URI:||https://hdl.handle.net/10356/155332||ISSN:||1523-7060||DOI:||10.1021/acs.orglett.0c00415||Rights:||© 2020 American Chemical Society. All rights reserved.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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