Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155332
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dc.contributor.authorChen, Yangen_US
dc.contributor.authorYang, Wenjieen_US
dc.contributor.authorWu, Jiaminen_US
dc.contributor.authorSun, Wangbinen_US
dc.contributor.authorLoh, Teck-Pengen_US
dc.contributor.authorJiang, Yaojiaen_US
dc.date.accessioned2022-03-18T05:50:37Z-
dc.date.available2022-03-18T05:50:37Z-
dc.date.issued2020-
dc.identifier.citationChen, Y., Yang, W., Wu, J., Sun, W., Loh, T. & Jiang, Y. (2020). 2H-azirines as potential bifunctional chemical linkers of cysteine residues in bioconjugate technology. Organic Letters, 22(5), 2038-2043. https://dx.doi.org/10.1021/acs.orglett.0c00415en_US
dc.identifier.issn1523-7060en_US
dc.identifier.urihttps://hdl.handle.net/10356/155332-
dc.description.abstract2H-Azirine-2-caboxamides have been designed to perform as a new type of bifunctional thiol linker under very mild reaction conditions. The cleavage of a C-N double bond of 2H-azirine furnishes an amino amide functional group in situ through a thiol addition and ring-opening process. It works with a broad scope of thiols and 2H-azirines in the absence of any catalysts at room temperature. Cysteine-containing peptides have also been demonstrated to work efficiently in a completely water solution.en_US
dc.language.isoenen_US
dc.relation.ispartofOrganic Lettersen_US
dc.rights© 2020 American Chemical Society. All rights reserved.en_US
dc.subjectScience::Chemistryen_US
dc.title2H-azirines as potential bifunctional chemical linkers of cysteine residues in bioconjugate technologyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1021/acs.orglett.0c00415-
dc.identifier.pmid32105086-
dc.identifier.scopus2-s2.0-85081945949-
dc.identifier.issue5en_US
dc.identifier.volume22en_US
dc.identifier.spage2038en_US
dc.identifier.epage2043en_US
dc.subject.keywordsBifunctional Thiol Linkeren_US
dc.subject.keywordsPeptides and Proteinsen_US
dc.description.acknowledgementWe gratefully acknowledge funding from the National Natural Science Foundation of China (21971112), Jiangsu Province Funds Surface Project (BK 20161541), and the Starting Funding of Research (39837107) from Nanjing Tech Universityen_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
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