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Title: Intermolecular reductive heck reaction of unactivated aliphatic alkenes with organohalides
Authors: Zheng, Kewang
Xiao, Guanlin
Guo, Tao
Ding, Yalan
Wang, Chengdong
Loh, Teck-Peng
Wu, Xiaojin
Keywords: Science::Chemistry
Issue Date: 2020
Source: Zheng, K., Xiao, G., Guo, T., Ding, Y., Wang, C., Loh, T. & Wu, X. (2020). Intermolecular reductive heck reaction of unactivated aliphatic alkenes with organohalides. Organic Letters, 22(2), 694-699.
Journal: Organic Letters
Abstract: A general intermolecular reductive Heck reaction of organohalides with both terminal and internal unactivated aliphatic alkenes has been first realized in high yield with complete anti-Markovnikov selectivity. The challenging vinyl bromides, aryl chlorides, and polysubstituted internal alkenes were first applied. More than 100 remote carbofunctionalized alkyl carboxylic acid derivatives were rapidly synthesized from easily accessible starting materials. The synthesis of drug molecules has further demonstrated the wide synthetic utility of this scalable strategy. Preliminary mechanistic studies are consistent with the proposed catalytic cycle.
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.9b04474
Rights: © 2020 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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