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Title: Water-stable all-inorganic perovskite nanocrystals with nonlinear optical properties for targeted multiphoton bioimaging
Authors: Chan, Kok Ken
Giovanni, David
He, Huajun
Sum, Tze Chien
Yong, Ken-Tye
Keywords: Engineering::Nanotechnology
Science::Physics::Optics and light
Science::Biological sciences::Biochemistry
Issue Date: 2021
Source: Chan, K. K., Giovanni, D., He, H., Sum, T. C. & Yong, K. (2021). Water-stable all-inorganic perovskite nanocrystals with nonlinear optical properties for targeted multiphoton bioimaging. ACS Applied Nano Materials, 4(9), 9022-9033.
Project: M4080514
Journal: ACS Applied Nano Materials
Abstract: CsPbX3nanocrystals have been employed in various optoelectronic applications, such as light-emitting diodes and solar cells. Nevertheless, widespread application of CsPbX3nanocrystals has been largely restricted by their poor aqueous stability. Despite the tremendous efforts focused on encapsulating the CsPbX3nanocrystals, it is still very challenging to achieve CsPbX3nanocrystals with good aqueous stability. This work describes the preparation and encapsulation methods for CsPbBr3/SiO2/mPEG-DSPE nanocrystals that can be readily dispersed in water and biological buffers. To the best of our knowledge, this is the first work that reports multiphoton emissions from CsPbBr3/SiO2/mPEG-DSPE nanocrystals in water. The protection afforded by the silica shell and phospholipid micelles enables the CsPbBr3/SiO2/mPEG-DSPE nanocrystals in aqueous solution to exhibit enhanced long-term stability and better shielding against ultrasonication treatment and continuous light irradiation than bare CsPbBr3nanocrystals. The toxicity of the CsPbBr3/SiO2/mPEG-DSPE nanocrystals has been evaluated in various cell lines. Subsequently, the encapsulated nanocrystals were used for targeted single and multiphoton imaging of cancer cells. This work not only describes the preparation of water-stable CsPbBr3nanocrystals but also paves the way for their applications in multiphoton bioimaging applications.
ISSN: 2574-0970
DOI: 10.1021/acsanm.1c01621
Schools: School of Physical and Mathematical Sciences 
School of Electrical and Electronic Engineering 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Nano Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
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