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Title: Association of nanoparticle exposure with serum metabolic disorders of healthy adults in printing centres
Authors: Jia, Shenglan
Setyawati, Magdiel Inggrid
Liu, Min
Xu, Tengfei
Loo, Joachim Say Chye
Yan, Meilin
Gong, Jicheng
Chotirmall, Sanjay Haresh
Demokritou, Philip
Ng, Kee Woei
Fang, Mingliang
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Jia, S., Setyawati, M. I., Liu, M., Xu, T., Loo, J. S. C., Yan, M., Gong, J., Chotirmall, S. H., Demokritou, P., Ng, K. W. & Fang, M. (2022). Association of nanoparticle exposure with serum metabolic disorders of healthy adults in printing centres. Journal of Hazardous Materials, 432, 128710-.
Project: NTU-HSPH 17001 
Journal: Journal of Hazardous Materials 
Abstract: Printers are everyday devices in both our homes and workplaces. We have previously found high occupational exposure levels to toner-based printer emitted nanoparticles (PEPs) at printing centers. To elucidate the potential health effects from exposure to PEPs, a total of 124 human serum samples were collected from 32 workers in the printing centers during the repeated follow-up measurements, and global serum metabolomics were analyzed in three ways: correlation between metabolic response and personal exposure (dose response exposure); metabolite response changes between Monday and Friday of a work week (short-term exposure), and metabolite response in relation to length of service in a center (long-term exposure). A total of 52 key metabolites changed significantly in relation to nanoparticle exposure levels. The primary dysregulated pathways included inflammation and immunity related arginine and tryptophan metabolism. Besides, some distinct metabolite expression patterns were found to occur during the transition from short-term to long-term exposures, suggesting cumulative effect of PEPs exposure. These findings, for the first time, highlight the inhalation exposure responses to printer emitted nanoparticles at the metabolite level, potentially serving as pre-requisites for whole organism and population responses, and are inline with emerging findings on potential health effects.
ISSN: 0304-3894
DOI: 10.1016/j.jhazmat.2022.128710
Rights: © 2022 Elsevier B.V. All rights reserved. This paper was published in Journal of Hazardous Materials and is made available with permission of Elsevier B.V.
Fulltext Permission: embargo_20240622
Fulltext Availability: With Fulltext
Appears in Collections:CEE Journal Articles
LKCMedicine Journal Articles
MSE Journal Articles
NEWRI Journal Articles

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