Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155843
Title: Solid-state fermented okara with Aspergillus spp. improves lipid metabolism and high-fat diet induced obesity
Authors: Ichikawa, Natsumi
Ng, Li Shiuan
Makino, Saneyuki
Goh, Luo Lin
Lim, Yun Jia
Ferdinandus
Sasaki, Hiroyuki
Shibata, Shigenobu
Lee, Ken Chi-Lik
Keywords: Science::Chemistry
Issue Date: 2022
Source: Ichikawa, N., Ng, L. S., Makino, S., Goh, L. L., Lim, Y. J., Ferdinandus, Sasaki, H., Shibata, S. & Lee, K. C. (2022). Solid-state fermented okara with Aspergillus spp. improves lipid metabolism and high-fat diet induced obesity. Metabolites, 12(3), 198-. https://dx.doi.org/10.3390/metabo12030198
Journal: Metabolites
Abstract: Okara is a major by-product of soymilk and tofu production. Despite retaining abundant nutrients after the process, okara is often under-utilized. In this study, solid-state fermentation (SSF) of okara was carried out using a koji starter (containing both Aspergillus oryzae and Aspergillus sojae) with the intention of releasing its untapped nutrients. Its effects on lipid metabolism in diet-induced obesity (DIO) were observed. The nutritional profile of fermented okara was elucidated using the following parameters: total phenolic content (TPC), pH, protein content, dietary fiber, amino acid content, and free sugar content. In vivo experiments were conducted using high-fat diets supplemented with unfermented okara and fermented okara over three weeks. Supplementation with fermented okara reduced body weight gain, adipose tissue weight, the serum triglyceride profile, and lipid accumulation in the liver, and altered the mRNA expression levels related to lipid metabolism; however, it did not affect pH and short-chain fatty acid (SCFA) production in this study. In conclusion, high-fat diets supplemented using okara fermented with Aspergillus spp. improved the lipid metabolism in mice, due to their high nutritional value, such as TPC, soy protein, and amino acids, and their synergistic effects without altering the gut microbiota.
URI: https://hdl.handle.net/10356/155843
ISSN: 2218-1989
DOI: 10.3390/metabo12030198
Rights: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

Page view(s)

26
Updated on May 20, 2022

Download(s)

10
Updated on May 20, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.