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Title: Serotonergic modulation of the claustrum
Authors: Wong, Kelly Li Lin
Keywords: Science::Biological sciences::Human anatomy and physiology::Neurobiology
Science::Biological sciences::Human anatomy and physiology
Issue Date: 2021
Publisher: Nanyang Technological University
Source: Wong, K. L. L. (2021). Serotonergic modulation of the claustrum. Doctoral thesis, Nanyang Technological University, Singapore.
Project: MOE2017-T3-1-002
Abstract: The claustrum, whose function is hotly debated, is a small but densely connected brain structure. How exactly the claustrum is modulated by neuromodulators, including serotonin (5-HT), is understudied. Here, 5-HT responses in individual claustral neurons were investigated using whole-cell patch clamp, pharmacology, and caged compounds in ex vivo mouse brain slices. Claustral projection neurons (PNs) frequently produced a long-lasting inhibitory outward current that is mediated by K+ ions and mainly 5-HT receptor (5-HTR) -1A. The 5-HT current hyperpolarizes PNs because it reduced the firing properties of these PNs via a linear input subtraction. 5-HTRs causing the hyperpolarization were located at the soma and dendrites of PNs. Contrasting the PNs, the three claustral interneurons studied were either excited or inhibited by 5-HT but were not highly responsive to 5-HT. Taken together, 5-HT creates a net inhibition in the claustrum and decreases the claustrum’s sensitivity to input.
DOI: 10.32657/10356/155926
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: embargo_20240324
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Theses

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