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Title: Self-assembled semiconducting polymer based hybrid nanoagents for synergistic tumor treatment
Authors: Bindra, Anivind Kaur
Wang, Dongdong
Zheng, Zesheng
Jana, Deblin
Zhou, Weiqiang
Yan, Suxia
Wu, Hongwei
Zheng, Yuanjin
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2021
Source: Bindra, A. K., Wang, D., Zheng, Z., Jana, D., Zhou, W., Yan, S., Wu, H., Zheng, Y. & Zhao, Y. (2021). Self-assembled semiconducting polymer based hybrid nanoagents for synergistic tumor treatment. Biomaterials, 279, 121188-.
Project: A20E5c0081
Journal: Biomaterials
Abstract: There is an impending need for the development of carrier-free nanosystems for single laser triggered activation of phototherapy, as such approach can overcome the drawbacks associated with irradiation by two distinct laser sources for avoiding prolonged treatment time and complex treatment protocols. Herein, we developed a self-assembled nanosystem (SCP-CS) consisting of a new semiconducting polymer (SCP) and encapsulated ultrasmall CuS (CS) nanoparticles. The SCP component displays remarkable near infrared (NIR) induced photothermal ability, enhanced reactive oxygen species (ROS) generation, and incredible photoacoustic (PA) signals upon activation by 808 nm laser for phototherapy mediated cancer ablation. The CuS component improves the PA imaging ability of SCP-CS, and also enhances photo-induced chemodynamic efficacy. Attributed to promoted single laser-triggered hyperthermia and enhanced ROS generation, the SCP-CS nanosystem shows effective intracellular uptake and intratumoral accumulation, enhanced tumor suppression with reduced treatment time, and devoid of any noticeable toxicity.
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2021.121188
Rights: © 2021 Elsevier Ltd. All rights reserved. This paper was published in Biomaterials and is made available with permission of Elsevier Ltd.
Fulltext Permission: embargo_20230107
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles
SCBE Journal Articles
SPMS Journal Articles

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