Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/155935
Title: | Single-atom engineering of metal-organic frameworks toward healthcare | Authors: | Wang, Dongdong Zhao, Yanli |
Keywords: | Science::Chemistry | Issue Date: | 2021 | Source: | Wang, D. & Zhao, Y. (2021). Single-atom engineering of metal-organic frameworks toward healthcare. Chem, 7(10), 2635-2671. https://dx.doi.org/10.1016/j.chempr.2021.08.020 | Project: | A20E5c0081 NRF-NRFI2018-03 |
Journal: | Chem | Abstract: | Single-atomic nanocatalysts/nanozymes (SACs/SAEs) have emerged as a research frontier on account of the maximum atom-utilization efficiency and well-defined localized structure. Metal-organic frameworks (MOFs) featuring the structural diversity and functional tunability are promising host materials in constructing SACs/SAEs. Further pyrolysis of MOF precursors under certain conditions can lead to the formations of MOF-derived SACs/SAEs. In this review, we first introduce the classification and enzymatic mechanisms of nanozymes, comprehensive characterization techniques for SACs/SAEs, and various synthetic methodologies of MOF-based SACs/SAEs. Next, we highlight the recent advances of MOF-based SACs/SAEs in the enzymatic healthcare area, i.e., cancer treatment, biosensing, anti-bacteria, reactive oxygen species scavenger, and environmental protection. Finally, we summarize the insights we gain from these studies, and discuss possible design principles and future challenges for a deeper understanding of this emerging field, thus offering great opportunities to leap over conventional nanozymes into a new era of next-generation biosafe SACs/SAEs. | URI: | https://hdl.handle.net/10356/155935 | ISSN: | 2451-9294 | DOI: | 10.1016/j.chempr.2021.08.020 | Schools: | School of Physical and Mathematical Sciences School of Chemical and Biomedical Engineering |
Rights: | © 2021 Elsevier Inc. All rights reserved. This paper was published in Chem and is made available with permission of Elsevier Inc. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles SPMS Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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Main Manuscript.pdf | 31.14 MB | Adobe PDF | View/Open |
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