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Title: Single-atom engineering of metal-organic frameworks toward healthcare
Authors: Wang, Dongdong
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2021
Source: Wang, D. & Zhao, Y. (2021). Single-atom engineering of metal-organic frameworks toward healthcare. Chem, 7(10), 2635-2671.
Project: A20E5c0081 
Journal: Chem 
Abstract: Single-atomic nanocatalysts/nanozymes (SACs/SAEs) have emerged as a research frontier on account of the maximum atom-utilization efficiency and well-defined localized structure. Metal-organic frameworks (MOFs) featuring the structural diversity and functional tunability are promising host materials in constructing SACs/SAEs. Further pyrolysis of MOF precursors under certain conditions can lead to the formations of MOF-derived SACs/SAEs. In this review, we first introduce the classification and enzymatic mechanisms of nanozymes, comprehensive characterization techniques for SACs/SAEs, and various synthetic methodologies of MOF-based SACs/SAEs. Next, we highlight the recent advances of MOF-based SACs/SAEs in the enzymatic healthcare area, i.e., cancer treatment, biosensing, anti-bacteria, reactive oxygen species scavenger, and environmental protection. Finally, we summarize the insights we gain from these studies, and discuss possible design principles and future challenges for a deeper understanding of this emerging field, thus offering great opportunities to leap over conventional nanozymes into a new era of next-generation biosafe SACs/SAEs.
ISSN: 2451-9294
DOI: 10.1016/j.chempr.2021.08.020
Schools: School of Physical and Mathematical Sciences 
School of Chemical and Biomedical Engineering 
Rights: © 2021 Elsevier Inc. All rights reserved. This paper was published in Chem and is made available with permission of Elsevier Inc.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles
SPMS Journal Articles

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