Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155937
Title: NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy
Authors: Chen, Hongzhong
Sun, Tao
Zeng, Weiwei
Zeng, Xiaowei
Mei, Lin
Jiang, Chen
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Chen, H., Sun, T., Zeng, W., Zeng, X., Mei, L., Jiang, C. & Zhao, Y. (2022). NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy. ACS Materials Letters, 4(1), 111-119. https://dx.doi.org/10.1021/acsmaterialslett.1c00677
Project: A20E5c0081
NRFNRFI2018-03
Journal: ACS Materials Letters
Abstract: Despite that photodynamic therapy (PDT) has promising clinical prospect, its therapeutic efficacy is still restricted by the hypoxic tumor microenvironment (TME). Therefore, how to suitably employ the tumor hypoxia is vital for optimizing PDT. Herein, we developed a hypoxia-activated prodrug for combination therapy with PDT. A hypoxia-responsive camptothecin (CPT)-based prodrug and a near-infrared (NIR) BODIPY photosensitizer were co-loaded within a -cyclodextrin-based polymer through supramolecular host-guest recognition to obtain nanoparticles named as CPT-BODIPY-PNs. After being internalized by tumor, the oxygen in the tumor tissues was rapidly consumed by the photosensitizer moiety to generate reactive oxygen species under NIR irradiation. The prodrug was efficiently activated under this intensified hypoxic condition to release chemotherapeutic CPT drug. This system makes the best use of hypoxia TME to achieve effectively combined PDT and chemotherapy, offering an approach for cancer treatment.
URI: https://hdl.handle.net/10356/155937
ISSN: 2639-4979
DOI: 10.1021/acsmaterialslett.1c00677
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Materials Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmaterialslett.1c00677.
Fulltext Permission: embargo_20230110
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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  Until 2023-01-10
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