Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155940
Title: Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy
Authors: Dong, Shuming
Dong, Yushan
Liu, Bin
Liu, Jing
Liu, Shikai
Zhao, Zhiyu
Li, Wenting
Tian, Boshi
Zhao, Ruoxi
He, Fei
Gai, Shili
Xie, Ying
Yang, Piaoping
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Dong, S., Dong, Y., Liu, B., Liu, J., Liu, S., Zhao, Z., Li, W., Tian, B., Zhao, R., He, F., Gai, S., Xie, Y., Yang, P. & Zhao, Y. (2022). Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy. Advanced Materials, 34(7), 2107054-. https://dx.doi.org/10.1002/adma.202107054
Project: A20E5c0081
NRF-NRFI2018-03
Journal: Advanced Materials
Abstract: Clinical applications of nanozyme-initiated chemodynamic therapy (NCDT) have been severely limited by poor catalytic efficiency of nanozymes, insufficient endogenous H2O2 content, and off-target consumption. Herein, we develop hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with elaborately regulated multi-enzymatic activities, i.e., simultaneously enhancing superoxide dismutase (SOD)-like and peroxidase (POD)-like activities and inhibiting catalase (CAT)-like activity, serving as an H2O2 homeostasis disruptor to promote H2O2 evolvement and restrain off-target elimination of H2O2 for achieving intensive NCDT. PHMZCO-AT nanozymes with SOD-like activity can catalyze endogenous O2·– into H2O2 in the tumor region. The suppression of CAT activity and depletion of glutathione by PHMZCO-AT largely weaken the off-target decomposition of H2O2 to H2O. Elevated H2O2 is then exclusively catalyzed by the downstream POD-like activity of PHMZCO-AT to generate toxic hydroxyl radicals, further inducing tumor apoptosis and death. T1-weighted magnetic resonance imaging and high-contrast X-ray computed tomography imaging are also achieved using PEG/PHMZCO-AT nanozymes due to the existence of paramagnetic Mn2+ species and high X-ray attenuation ability of elemental Zr, permitting in vivo tracking of the therapeutic process. This work presents a powerful paradigm to achieve intensive NCDT efficacy by simultaneously regulating multi-enzymatic activities of Ce-based nanozymes and perturbing the H2O2 homeostasis in tumor microenvironment.
URI: https://hdl.handle.net/10356/155940
ISSN: 0935-9648
DOI: 10.1002/adma.202107054
Rights: This is the peer reviewed version of the following article: Dong, S., Dong, Y., Liu, B., Liu, J., Liu, S., Zhao, Z., Li, W., Tian, B., Zhao, R., He, F., Gai, S., Xie, Y., Yang, P. & Zhao, Y. (2022). Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy. Advanced Materials, 34(7), 2107054, which has been published in final form at https://doi.org/10.1002/adma.202107054. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: embargo_20230224
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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