Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155940
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDong, Shumingen_US
dc.contributor.authorDong, Yushanen_US
dc.contributor.authorLiu, Binen_US
dc.contributor.authorLiu, Jingen_US
dc.contributor.authorLiu, Shikaien_US
dc.contributor.authorZhao, Zhiyuen_US
dc.contributor.authorLi, Wentingen_US
dc.contributor.authorTian, Boshien_US
dc.contributor.authorZhao, Ruoxien_US
dc.contributor.authorHe, Feien_US
dc.contributor.authorGai, Shilien_US
dc.contributor.authorXie, Yingen_US
dc.contributor.authorYang, Piaopingen_US
dc.contributor.authorZhao, Yanlien_US
dc.date.accessioned2022-03-25T07:50:59Z-
dc.date.available2022-03-25T07:50:59Z-
dc.date.issued2022-
dc.identifier.citationDong, S., Dong, Y., Liu, B., Liu, J., Liu, S., Zhao, Z., Li, W., Tian, B., Zhao, R., He, F., Gai, S., Xie, Y., Yang, P. & Zhao, Y. (2022). Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy. Advanced Materials, 34(7), 2107054-. https://dx.doi.org/10.1002/adma.202107054en_US
dc.identifier.issn0935-9648en_US
dc.identifier.urihttps://hdl.handle.net/10356/155940-
dc.description.abstractClinical applications of nanozyme-initiated chemodynamic therapy (NCDT) have been severely limited by poor catalytic efficiency of nanozymes, insufficient endogenous H2O2 content, and off-target consumption. Herein, we develop hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with elaborately regulated multi-enzymatic activities, i.e., simultaneously enhancing superoxide dismutase (SOD)-like and peroxidase (POD)-like activities and inhibiting catalase (CAT)-like activity, serving as an H2O2 homeostasis disruptor to promote H2O2 evolvement and restrain off-target elimination of H2O2 for achieving intensive NCDT. PHMZCO-AT nanozymes with SOD-like activity can catalyze endogenous O2·– into H2O2 in the tumor region. The suppression of CAT activity and depletion of glutathione by PHMZCO-AT largely weaken the off-target decomposition of H2O2 to H2O. Elevated H2O2 is then exclusively catalyzed by the downstream POD-like activity of PHMZCO-AT to generate toxic hydroxyl radicals, further inducing tumor apoptosis and death. T1-weighted magnetic resonance imaging and high-contrast X-ray computed tomography imaging are also achieved using PEG/PHMZCO-AT nanozymes due to the existence of paramagnetic Mn2+ species and high X-ray attenuation ability of elemental Zr, permitting in vivo tracking of the therapeutic process. This work presents a powerful paradigm to achieve intensive NCDT efficacy by simultaneously regulating multi-enzymatic activities of Ce-based nanozymes and perturbing the H2O2 homeostasis in tumor microenvironment.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationA20E5c0081en_US
dc.relationNRF-NRFI2018-03en_US
dc.relation.ispartofAdvanced Materialsen_US
dc.rightsThis is the peer reviewed version of the following article: Dong, S., Dong, Y., Liu, B., Liu, J., Liu, S., Zhao, Z., Li, W., Tian, B., Zhao, R., He, F., Gai, S., Xie, Y., Yang, P. & Zhao, Y. (2022). Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy. Advanced Materials, 34(7), 2107054, which has been published in final form at https://doi.org/10.1002/adma.202107054. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectScience::Chemistryen_US
dc.titleGuiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1002/adma.202107054-
dc.description.versionSubmitted/Accepted versionen_US
dc.identifier.issue7en_US
dc.identifier.volume34en_US
dc.identifier.spage2107054en_US
dc.subject.keywordsCancer Treatmenten_US
dc.subject.keywordsChemodynamic Therapyen_US
dc.description.acknowledgementThe work was supported by the MOST Grant (2016YFA0101202), the National Natural Science Foundation of China (51972075 and 51772059), the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081), the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03), and the Fundamental Research Funds for the Central Universities.en_US
item.fulltextWith Fulltext-
item.grantfulltextembargo_20230224-
Appears in Collections:SPMS Journal Articles
Files in This Item:
File Description SizeFormat 
Manuscript.pdf
  Until 2023-02-24
13.61 MBAdobe PDFUnder embargo until Feb 24, 2023

Page view(s)

37
Updated on Jul 5, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.