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https://hdl.handle.net/10356/155942
Title: | Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment | Authors: | Wang, Dongdong He, Isabel Wenjia Liu, Jiawei Jana, Deblin Wu, Yinglong Zhang, Xiaodong Qian, Cheng Guo, Yi Chen, Xiaokai Bindra, Anivind Kaur Zhao, Yanli |
Keywords: | Science::Chemistry | Issue Date: | 2021 | Source: | Wang, D., He, I. W., Liu, J., Jana, D., Wu, Y., Zhang, X., Qian, C., Guo, Y., Chen, X., Bindra, A. K. & Zhao, Y. (2021). Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angewandte Chemie International Edition, 60(50), 26254-26259. https://dx.doi.org/10.1002/anie.202112128 | Project: | A20E5c0081 NRF-NRFI2018-03 |
Journal: | Angewandte Chemie International Edition | Abstract: | Clinical translation of artesunate (ATS) as a potent antitumor drug has been obstructed by its rapid degradation and low bioavailability. Herein, we report the development of ATS nanomedicine through the self-assembly with Mn[Co(CN)6]2/31/3 metal-organic frameworks (MOFs) having hidden missing linkers. The defects originated from the missing linkers play a key role in increasing the biological stability and tumor accumulation of ATS. Chlorin e6 (Ce6) and ATS can be co-loaded into MOFs for a synergistic antitumor efficacy. In the presence of intracellular HCO3-, Mn2+ acts as an efficient catalyst to promote the bicarbonate-activated H2O2 system and induce oxidative death to cancer cells based on ATS with an endoperoxide bridge. The released [CoIII(CN)6] linker undergoes a redox reaction with intracellular glutathione to prevent the scavenging ability of reactive oxygen species, contributing to synergistic chemodynamic therapy of ATS and photodynamic therapy of Ce6. Thus, defect-engineered MOFs with hidden missing linkers hold great promises in advancing the practical uses of ATS as an antitumor medicine. | URI: | https://hdl.handle.net/10356/155942 | ISSN: | 1433-7851 | DOI: | 10.1002/anie.202112128 | Schools: | School of Physical and Mathematical Sciences | Rights: | This is the peer reviewed version of the following article: Wang, D., He, I. W., Liu, J., Jana, D., Wu, Y., Zhang, X., Qian, C., Guo, Y., Chen, X., Bindra, A. K. & Zhao, Y. (2021). Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angewandte Chemie International Edition, 60(50), 26254-26259, which has been published in final form at https://doi.org/10.1002/anie.202112128. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles SPMS Journal Articles |
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Manuscript.pdf | 15.75 MB | Adobe PDF | View/Open |
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