Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155942
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dc.contributor.authorWang, Dongdongen_US
dc.contributor.authorHe, Isabel Wenjiaen_US
dc.contributor.authorLiu, Jiaweien_US
dc.contributor.authorJana, Deblinen_US
dc.contributor.authorWu, Yinglongen_US
dc.contributor.authorZhang, Xiaodongen_US
dc.contributor.authorQian, Chengen_US
dc.contributor.authorGuo, Yien_US
dc.contributor.authorChen, Xiaokaien_US
dc.contributor.authorBindra, Anivind Kauren_US
dc.contributor.authorZhao, Yanlien_US
dc.date.accessioned2022-03-25T01:42:23Z-
dc.date.available2022-03-25T01:42:23Z-
dc.date.issued2021-
dc.identifier.citationWang, D., He, I. W., Liu, J., Jana, D., Wu, Y., Zhang, X., Qian, C., Guo, Y., Chen, X., Bindra, A. K. & Zhao, Y. (2021). Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angewandte Chemie International Edition, 60(50), 26254-26259. https://dx.doi.org/10.1002/anie.202112128en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttps://hdl.handle.net/10356/155942-
dc.description.abstractClinical translation of artesunate (ATS) as a potent antitumor drug has been obstructed by its rapid degradation and low bioavailability. Herein, we report the development of ATS nanomedicine through the self-assembly with Mn[Co(CN)6]2/31/3 metal-organic frameworks (MOFs) having hidden missing linkers. The defects originated from the missing linkers play a key role in increasing the biological stability and tumor accumulation of ATS. Chlorin e6 (Ce6) and ATS can be co-loaded into MOFs for a synergistic antitumor efficacy. In the presence of intracellular HCO3-, Mn2+ acts as an efficient catalyst to promote the bicarbonate-activated H2O2 system and induce oxidative death to cancer cells based on ATS with an endoperoxide bridge. The released [CoIII(CN)6] linker undergoes a redox reaction with intracellular glutathione to prevent the scavenging ability of reactive oxygen species, contributing to synergistic chemodynamic therapy of ATS and photodynamic therapy of Ce6. Thus, defect-engineered MOFs with hidden missing linkers hold great promises in advancing the practical uses of ATS as an antitumor medicine.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationA20E5c0081en_US
dc.relationNRF-NRFI2018-03en_US
dc.relation.ispartofAngewandte Chemie International Editionen_US
dc.rightsThis is the peer reviewed version of the following article: Wang, D., He, I. W., Liu, J., Jana, D., Wu, Y., Zhang, X., Qian, C., Guo, Y., Chen, X., Bindra, A. K. & Zhao, Y. (2021). Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angewandte Chemie International Edition, 60(50), 26254-26259, which has been published in final form at https://doi.org/10.1002/anie.202112128. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectScience::Chemistryen_US
dc.titleMissing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatmenten_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1002/anie.202112128-
dc.description.versionSubmitted/Accepted versionen_US
dc.identifier.issue50en_US
dc.identifier.volume60en_US
dc.identifier.spage26254en_US
dc.identifier.epage26259en_US
dc.subject.keywordsArtesunateen_US
dc.subject.keywordsMetal–Organic Frameworken_US
dc.description.acknowledgementThis research is supported by the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081) and the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03).en_US
item.grantfulltextembargo_20221213-
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