Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155942
Title: Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment
Authors: Wang, Dongdong
He, Isabel Wenjia
Liu, Jiawei
Jana, Deblin
Wu, Yinglong
Zhang, Xiaodong
Qian, Cheng
Guo, Yi
Chen, Xiaokai
Bindra, Anivind Kaur
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2021
Source: Wang, D., He, I. W., Liu, J., Jana, D., Wu, Y., Zhang, X., Qian, C., Guo, Y., Chen, X., Bindra, A. K. & Zhao, Y. (2021). Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angewandte Chemie International Edition, 60(50), 26254-26259. https://dx.doi.org/10.1002/anie.202112128
Project: A20E5c0081
NRF-NRFI2018-03
Journal: Angewandte Chemie International Edition
Abstract: Clinical translation of artesunate (ATS) as a potent antitumor drug has been obstructed by its rapid degradation and low bioavailability. Herein, we report the development of ATS nanomedicine through the self-assembly with Mn[Co(CN)6]2/31/3 metal-organic frameworks (MOFs) having hidden missing linkers. The defects originated from the missing linkers play a key role in increasing the biological stability and tumor accumulation of ATS. Chlorin e6 (Ce6) and ATS can be co-loaded into MOFs for a synergistic antitumor efficacy. In the presence of intracellular HCO3-, Mn2+ acts as an efficient catalyst to promote the bicarbonate-activated H2O2 system and induce oxidative death to cancer cells based on ATS with an endoperoxide bridge. The released [CoIII(CN)6] linker undergoes a redox reaction with intracellular glutathione to prevent the scavenging ability of reactive oxygen species, contributing to synergistic chemodynamic therapy of ATS and photodynamic therapy of Ce6. Thus, defect-engineered MOFs with hidden missing linkers hold great promises in advancing the practical uses of ATS as an antitumor medicine.
URI: https://hdl.handle.net/10356/155942
ISSN: 1433-7851
DOI: 10.1002/anie.202112128
Rights: This is the peer reviewed version of the following article: Wang, D., He, I. W., Liu, J., Jana, D., Wu, Y., Zhang, X., Qian, C., Guo, Y., Chen, X., Bindra, A. K. & Zhao, Y. (2021). Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angewandte Chemie International Edition, 60(50), 26254-26259, which has been published in final form at https://doi.org/10.1002/anie.202112128. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: embargo_20221213
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles
SPMS Journal Articles

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