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Title: Developing a normative database for retinal perfusion using optical coherence tomography angiography
Authors: Tan, Bingyao
Sim, Yin Ci
Chua, Jacqueline
Yusufi, Dheo
Wong, Damon Wing Kee
Yow, Ai Ping
Chin, Calvin
Tan, Anna C. S.
Sng, Chelvin Cheryl Agnes
Agrawal, Rupesh
Gopal, Lekha
Sim, Ralene
Tan, Gavin
Lamoureux, Ecosse
Schmetterer, Leopold
Keywords: Engineering::General
Science::Medicine::Optical instruments
Issue Date: 2021
Source: Tan, B., Sim, Y. C., Chua, J., Yusufi, D., Wong, D. W. K., Yow, A. P., Chin, C., Tan, A. C. S., Sng, C. C. A., Agrawal, R., Gopal, L., Sim, R., Tan, G., Lamoureux, E. & Schmetterer, L. (2021). Developing a normative database for retinal perfusion using optical coherence tomography angiography. Biomedical Optics Express, 12(7), 4032-4045.
Project: NMRC/CG/C010A/2017_SERI 
Journal: Biomedical Optics Express 
Abstract: Visualizing and characterizing microvascular abnormalities with optical coherence tomography angiography (OCTA) has deepened our understanding of ocular diseases, such as glaucoma, diabetic retinopathy, and age-related macular degeneration. Two types of microvascular defects can be detected by OCTA: focal decrease because of localized absence and collapse of retinal capillaries, which is referred to as the non-perfusion area in OCTA, and diffuse perfusion decrease usually detected by comparing with healthy case-control groups. Wider OCTA allows for insights into peripheral retinal vascularity, but the heterogeneous perfusion distribution from the macula, parapapillary area to periphery hurdles the quantitative assessment. A normative database for OCTA could estimate how much individual's data deviate from the normal range, and where the deviations locate. Here, we acquired OCTA images using a swept-source OCT system and a 12×12 mm protocol in healthy subjects. We automatically segmented the large blood vessels with U-Net, corrected for anatomical factors such as the relative position of fovea and disc, and segmented the capillaries by a moving window scheme. A total of 195 eyes were included and divided into 4 age groups: < 30 (n=24) years old, 30-49 (n=28) years old, 50-69 (n=109) years old and >69 (n=34) years old. This provides an age-dependent normative database for characterizing retinal perfusion abnormalities in 12×12 mm OCTA images. The usefulness of the normative database was tested on two pathological groups: one with diabetic retinopathy; the other with glaucoma.
ISSN: 2156-7085
DOI: 10.1364/BOE.423469
Rights: © 2021 Optical Society of America under the terms of the Open Access Publishing Agreement. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for noncommercial purposes and appropriate attribution is maintained. All other rights are reserved.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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