Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156186
Title: Segregation of neuronal-vascular components in a retinal nerve fiber layer for thickness measurement using OCT and OCT angiography
Authors: Yow, Ai Ping
Tan, Bingyao
Chua, Jacqueline
Husain, Rahat
Schmetterer, Leopold
Wong, Damon Wing Kee
Keywords: Engineering::Chemical engineering
Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics
Issue Date: 2021
Source: Yow, A. P., Tan, B., Chua, J., Husain, R., Schmetterer, L. & Wong, D. W. K. (2021). Segregation of neuronal-vascular components in a retinal nerve fiber layer for thickness measurement using OCT and OCT angiography. Biomedical Optics Express, 12(6), 3228-3240. https://dx.doi.org/10.1364/BOE.420507
Journal: Biomedical Optics Express 
Abstract: Assessment of the circumpapillary retinal nerve fiber layer (RNFL) provides crucial knowledge on the status of the optic nerve. Current circumpapillary RNFL measurements consider only thickness, but an accurate evaluation should also consider blood vessel contribution. Previous studies considered the presence of major vessels in RNFL thickness measurements from optical coherence tomography (OCT). However, such quantitative measurements do not account for smaller vessels, which could also affect circumpapillary RNFL measurements. We present an approach to automatically segregate the neuronal and vascular components in circumpapillary RNFL by combining vascular information from OCT angiography (OCTA) and structural data from OCT. Automated segmentation of the circumpapillary RNFL using a state-of-the-art deep learning network is first performed and followed by the lateral and depth-resolved localization of the vascular component by vertically projecting the vessels along the circular scan from OCTA vessels map onto the segmented RNFL. Using this proposed approach, we compare the correlations of circumpapillary RNFL thicknesses with age at different levels of vessel exclusion (exclusion of major vessels only vs both major- and micro-vessels) and also evaluate the thickness variability in 75 healthy eyes. Our results show that the ratio of major- and micro-vessels to circumpapillary RNFL achieved a stronger correlation with aging (r = 0.478, P < .001) than the ratio with only major vessels to circumpapillary RNFL (r = 0.027, P = .820). Exclusion of blood vessels from circumpapillary RNFL thickness using OCTA imaging provides a better measure of the neuronal components and could potentially improve the diagnostic performance for disease detection.
URI: https://hdl.handle.net/10356/156186
ISSN: 2156-7085
DOI: 10.1364/BOE.420507
Rights: © 2021 Optical Society of America under the terms of the Open Access Publishing Agreement. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for noncommercial purposes and appropriate attribution is maintained. All other rights are reserved.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:IDMxS Journal Articles
SCBE Journal Articles

SCOPUSTM   
Citations 50

1
Updated on Apr 11, 2022

PublonsTM
Citations 50

1
Updated on Apr 11, 2022

Page view(s)

34
Updated on Jun 24, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.