Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156249
Title: Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs
Authors: Low, Celine Yan Jing
Keywords: Engineering::Materials
Issue Date: 2022
Publisher: Nanyang Technological University
Source: Low, C. Y. J. (2022). Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/156249
Abstract: Solid lipid microparticles (LMP) are alternatives to polymeric nanoparticles for the encapsulation of hydrophobic components that have poor bioavailability. However, the usual method of fabrication of solid LMP through high pressure homogenization had limitations that caused low encapsulation efficiency and potential damage to sensitive molecules. Hence the electrospray technique was investigated as an alternative. In this study, for the fabrication of solid LMP, the electrospray method was explored by varying different parameters such as flow rate and voltage. Scanning Electron Microscopy (SEM) was used to characterize the microparticles. Following the optimization of parameters, curcumin was loaded into the microparticle. Release studies of the curcumin loaded particles in simulated gastrointestinal fluids showed that the encapsulation was able to retard the release of curcumin in simulated gastric fluid (SGF) and release it in the simulated intestinal fluid (SIF). In order to prolong the release of curcumin, the curcumin loaded LMP were further encapsulated into floating particles that can act as a reservoir for LMP. Based on SEM images it was observed that the LMP were mainly localized on the surface of the floating microparticles. Further in vitro release studies on the floating particles need to be conducted to understand the behavior of LMP in the floating particles.
URI: https://hdl.handle.net/10356/156249
Fulltext Permission: embargo_restricted_20240408
Fulltext Availability: With Fulltext
Appears in Collections:MSE Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
Celine's FYP Report.pdf
  Until 2024-04-08
1.37 MBAdobe PDFUnder embargo until Apr 08, 2024

Page view(s)

30
Updated on Jul 2, 2022

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.