Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156351
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dc.contributor.authorZheng, Naen_US
dc.contributor.authorLin, Junquanen_US
dc.contributor.authorChin, Jiah Shinen_US
dc.contributor.authorWiraja, Christianen_US
dc.contributor.authorXu, Chenjieen_US
dc.contributor.authorMcGrouther, Duncan Angusen_US
dc.contributor.authorChew, Sing Yianen_US
dc.date.accessioned2022-04-17T12:25:25Z-
dc.date.available2022-04-17T12:25:25Z-
dc.date.issued2022-
dc.identifier.citationZheng, N., Lin, J., Chin, J. S., Wiraja, C., Xu, C., McGrouther, D. A. & Chew, S. Y. (2022). Delivery of Wnt inhibitor WIF1 via engineered polymeric microspheres promotes nerve regeneration after sciatic nerve crush. Journal of Tissue Engineering, 13, 1-14. https://dx.doi.org/10.1177/20417314221087417en_US
dc.identifier.issn2041-7314en_US
dc.identifier.urihttps://hdl.handle.net/10356/156351-
dc.description.abstractInjuries within the peripheral nervous system (PNS) lead to sensory and motor deficits, as well as neuropathic pain, which strongly impair the life quality of patients. Although most current PNS injury treatment approaches focus on using growth factors/small molecules to stimulate the regrowth of the injured nerves, these methods neglect another important factor that strongly hinders axon regeneration - the presence of axonal inhibitory molecules. Therefore, this work sought to explore the potential of pathway inhibition in promoting sciatic nerve regeneration. Additionally, the therapeutic window for using pathway inhibitors was uncovered so as to achieve the desired regeneration outcomes. Specifically, we explored the role of Wnt signaling inhibition on PNS regeneration by delivering Wnt inhibitors, sFRP2 and WIF1, after sciatic nerve transection and sciatic nerve crush injuries. Our results demonstrate that WIF1 promoted nerve regeneration (p < 0.05) after sciatic nerve crush injury. More importantly, we revealed the therapeutic window for the treatment of Wnt inhibitors, which is one week post sciatic nerve crush when the non-canonical receptor tyrosine kinase (Ryk) is significantly upregulated.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationSHS-NTU/038/2016en_US
dc.relationRG37/20en_US
dc.relation.ispartofJournal of Tissue Engineeringen_US
dc.rights© 2022 The Author(s). This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleDelivery of Wnt inhibitor WIF1 via engineered polymeric microspheres promotes nerve regeneration after sciatic nerve crushen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.researchNTU Institute for Health Technologiesen_US
dc.identifier.doi10.1177/20417314221087417-
dc.description.versionPublished versionen_US
dc.identifier.volume13en_US
dc.identifier.spage1en_US
dc.identifier.epage14en_US
dc.subject.keywordsPeripheral Nerve Injuryen_US
dc.subject.keywordsNerve Guidance Conduitsen_US
dc.description.acknowledgementFinancial support was received from SingHealth-NTU research collaborative grant (SHS-NTU/038/2016) and MOE AcRF Tier 1 grant (RG37/20).en_US
item.grantfulltextopen-
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Appears in Collections:IGS Journal Articles
LKCMedicine Journal Articles
MSE Journal Articles
SCBE Journal Articles

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