Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156351
Title: Delivery of Wnt inhibitor WIF1 via engineered polymeric microspheres promotes nerve regeneration after sciatic nerve crush
Authors: Zheng, Na
Lin, Junquan
Chin, Jiah Shin
Wiraja, Christian
Xu, Chenjie
McGrouther, Duncan Angus
Chew, Sing Yian
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Zheng, N., Lin, J., Chin, J. S., Wiraja, C., Xu, C., McGrouther, D. A. & Chew, S. Y. (2022). Delivery of Wnt inhibitor WIF1 via engineered polymeric microspheres promotes nerve regeneration after sciatic nerve crush. Journal of Tissue Engineering, 13, 1-14. https://dx.doi.org/10.1177/20417314221087417
Project: SHS-NTU/038/2016
RG37/20
Journal: Journal of Tissue Engineering
Abstract: Injuries within the peripheral nervous system (PNS) lead to sensory and motor deficits, as well as neuropathic pain, which strongly impair the life quality of patients. Although most current PNS injury treatment approaches focus on using growth factors/small molecules to stimulate the regrowth of the injured nerves, these methods neglect another important factor that strongly hinders axon regeneration - the presence of axonal inhibitory molecules. Therefore, this work sought to explore the potential of pathway inhibition in promoting sciatic nerve regeneration. Additionally, the therapeutic window for using pathway inhibitors was uncovered so as to achieve the desired regeneration outcomes. Specifically, we explored the role of Wnt signaling inhibition on PNS regeneration by delivering Wnt inhibitors, sFRP2 and WIF1, after sciatic nerve transection and sciatic nerve crush injuries. Our results demonstrate that WIF1 promoted nerve regeneration (p < 0.05) after sciatic nerve crush injury. More importantly, we revealed the therapeutic window for the treatment of Wnt inhibitors, which is one week post sciatic nerve crush when the non-canonical receptor tyrosine kinase (Ryk) is significantly upregulated.
URI: https://hdl.handle.net/10356/156351
ISSN: 2041-7314
DOI: 10.1177/20417314221087417
Rights: © 2022 The Author(s). This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles
LKCMedicine Journal Articles
MSE Journal Articles
SCBE Journal Articles

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