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Title: | A stretchable and transparent electrode based on PEGylated silk fibroin for in vivo dual-modal neural-vascular activity probing | Authors: | Cui, Yajing Zhang, Fan Chen, Geng Yao, Lin Zhang, Nan Liu, Zhiyuan Li, Qingsong Zhang, Feilong Cui, Zequn Zhang, Keqin Li, Peng Cheng, Yuan Zhang, Shaomin Chen, Xiaodong |
Keywords: | Engineering::Materials | Issue Date: | 2021 | Source: | Cui, Y., Zhang, F., Chen, G., Yao, L., Zhang, N., Liu, Z., Li, Q., Zhang, F., Cui, Z., Zhang, K., Li, P., Cheng, Y., Zhang, S. & Chen, X. (2021). A stretchable and transparent electrode based on PEGylated silk fibroin for in vivo dual-modal neural-vascular activity probing. Advanced Materials, 33(34), 2100221-. https://dx.doi.org/10.1002/adma.202100221 | Project: | NRF-NRFI2017-07 | Journal: | Advanced Materials | Abstract: | Transparent electrodes that form seamless contact and enable optical interrogation at the electrode-brain interface are potentially of high significance for neuroscience studies. Silk hydrogels can offer an ideal platform for transparent neural interfaces owing to their superior biocompatibility. However, conventional silk hydrogels are too weak and have difficulties integrating with highly conductive and stretchable electronics. Here, a transparent and stretchable hydrogel electrode based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and PEGylated silk protein is reported. PEGylated silk protein with poly(ethylene glycol) diglycidyl ether (PEGDE) improves the Young's modulus to 1.51-10.73 MPa and the stretchability to ≈400% from conventional silk hydrogels (<10 kPa). The PEGylated silk also helps form a robust interface with PEDOT:PSS thin film, making the hydrogel electrode synergistically incorporate superior stretchability (≈260%), stable electrical performance (≈4 months), and a low sheet resistance (≈160 ± 56 Ω sq-1 ). Finally, the electrode facilitates efficient electrical recording, and stimulation with unobstructed optical interrogation and rat-brain imaging are demonstrated. The highly transparent and stretchable hydrogel electrode offers a practical tool for neuroscience and paves the way for a harmonized tissue-electrode interface. | URI: | https://hdl.handle.net/10356/156393 | ISSN: | 0935-9648 | DOI: | 10.1002/adma.202100221 | Schools: | School of Materials Science and Engineering | Research Centres: | Innovative Centre for Flexible Devices Max Planck-NTU Joint Lab for Artificial Senses |
Rights: | This is the peer reviewed version of the following article: Cui, Y., Zhang, F., Chen, G., Yao, L., Zhang, N., Liu, Z., Li, Q., Zhang, F., Cui, Z., Zhang, K., Li, P., Cheng, Y., Zhang, S. & Chen, X. (2021). A stretchable and transparent electrode based on PEGylated silk fibroin for in vivo dual-modal neural-vascular activity probing. Advanced Materials, 33(34), 2100221-, which has been published in final form at https://doi.org/10.1002/adma.202100221. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | MSE Journal Articles |
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