Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156393
Title: A stretchable and transparent electrode based on PEGylated silk fibroin for in vivo dual-modal neural-vascular activity probing
Authors: Cui, Yajing
Zhang, Fan
Chen, Geng
Yao, Lin
Zhang, Nan
Liu, Zhiyuan
Li, Qingsong
Zhang, Feilong
Cui, Zequn
Zhang, Keqin
Li, Peng
Cheng, Yuan
Zhang, Shaomin
Chen, Xiaodong
Keywords: Engineering::Materials
Issue Date: 2021
Source: Cui, Y., Zhang, F., Chen, G., Yao, L., Zhang, N., Liu, Z., Li, Q., Zhang, F., Cui, Z., Zhang, K., Li, P., Cheng, Y., Zhang, S. & Chen, X. (2021). A stretchable and transparent electrode based on PEGylated silk fibroin for in vivo dual-modal neural-vascular activity probing. Advanced Materials, 33(34), 2100221-. https://dx.doi.org/10.1002/adma.202100221
Project: NRF-NRFI2017-07
Journal: Advanced Materials
Abstract: Transparent electrodes that form seamless contact and enable optical interrogation at the electrode-brain interface are potentially of high significance for neuroscience studies. Silk hydrogels can offer an ideal platform for transparent neural interfaces owing to their superior biocompatibility. However, conventional silk hydrogels are too weak and have difficulties integrating with highly conductive and stretchable electronics. Here, a transparent and stretchable hydrogel electrode based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and PEGylated silk protein is reported. PEGylated silk protein with poly(ethylene glycol) diglycidyl ether (PEGDE) improves the Young's modulus to 1.51-10.73 MPa and the stretchability to ≈400% from conventional silk hydrogels (<10 kPa). The PEGylated silk also helps form a robust interface with PEDOT:PSS thin film, making the hydrogel electrode synergistically incorporate superior stretchability (≈260%), stable electrical performance (≈4 months), and a low sheet resistance (≈160 ± 56 Ω sq-1 ). Finally, the electrode facilitates efficient electrical recording, and stimulation with unobstructed optical interrogation and rat-brain imaging are demonstrated. The highly transparent and stretchable hydrogel electrode offers a practical tool for neuroscience and paves the way for a harmonized tissue-electrode interface.
URI: https://hdl.handle.net/10356/156393
ISSN: 0935-9648
DOI: 10.1002/adma.202100221
Rights: This is the peer reviewed version of the following article: Cui, Y., Zhang, F., Chen, G., Yao, L., Zhang, N., Liu, Z., Li, Q., Zhang, F., Cui, Z., Zhang, K., Li, P., Cheng, Y., Zhang, S. & Chen, X. (2021). A stretchable and transparent electrode based on PEGylated silk fibroin for in vivo dual-modal neural-vascular activity probing. Advanced Materials, 33(34), 2100221-, which has been published in final form at https://doi.org/10.1002/adma.202100221. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: embargo_20220903
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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