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Title: Syntheses and applications of phosphine- N- heterocyclic carbene metal complexes via catalytic asymmetric hydrophosphination
Authors: Seah, Jeffery Wee Kiong
Keywords: Science::Chemistry
Issue Date: 2021
Publisher: Nanyang Technological University
Source: Seah, J. W. K. (2021). Syntheses and applications of phosphine- N- heterocyclic carbene metal complexes via catalytic asymmetric hydrophosphination. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Chiral hybrid phosphine- N-heterocyclic carbenes form a unique class of bidentate ligands which finds extensive uses as privileged ligands in homogeneous transition metal catalysis. The current methodologies associated with their syntheses suffer from significant drawbacks and the diversity of the structural backbones of these ligands has hence been limited. Catalytic asymmetric hydrophosphination was contrived as a solution to address the abovementioned problem as it is arguably one of the most efficient methods of generating chiral phosphines with high enantiopurities and simultaneously, offering additional advantages such as a 100% atom economy, mild reaction conditions and a diverse substrate scope. Catalytic asymmetric hydrophosphination was employed in the syntheses of novel chiral phosphine- N- heterocyclic carbene precursors and these precursors were subsequently transformed into chiral novel phosphine- N- heterocyclic carbene metal complexes. The structures of the complexes were elucidated via X-ray crystallography and their catalytic and biological applications were explored.
DOI: 10.32657/10356/156396
Schools: School of Physical and Mathematical Sciences 
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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