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https://hdl.handle.net/10356/156675
Title: | Albumin-based therapeutics capable of glutathione consumption and hydrogen peroxide generation for synergetic chemodynamic and chemotherapy of cancer | Authors: | Yang, Guangbao Wang, Dongdong Phua, Fiona Soo Zeng Bindra, Anivind Kaur Qian, Cheng Zheng, Rui Cheng, Liang Liu, Guofeng Wu, Hongwei Liu, Zhuang Zhao, Yanli |
Keywords: | Science::Chemistry | Issue Date: | 2022 | Source: | Yang, G., Wang, D., Phua, F. S. Z., Bindra, A. K., Qian, C., Zheng, R., Cheng, L., Liu, G., Wu, H., Liu, Z. & Zhao, Y. (2022). Albumin-based therapeutics capable of glutathione consumption and hydrogen peroxide generation for synergetic chemodynamic and chemotherapy of cancer. ACS Nano, 16(2), 2319-2329. https://dx.doi.org/10.1021/acsnano.1c08536 | Project: | A20E5c0081 NRF-NRFI2018-03 |
Journal: | ACS Nano | Abstract: | A nanoscale therapeutic system with good biocompatibility was facilely fabricated by the coassembly of human serum albumin and glucose oxidase (GOD), where the former was pretreated with metal ions through a chelating agent or the chemotherapeutic prodrug oxaliplatin (Oxa(IV)). Among different chelating metal ions used, Mn2+ ion was selected to produce hydroxyl radical (•OH) efficiently through Fenton-like reaction, while GOD loaded in the system was able to generate a large amount of hydrogen peroxide for promoting efficient conversion into highly toxic •OH. In the meanwhile, the conversion of the Oxa(IV) prodrug into chemotherapeutic Oxa(II) was beneficial for the consumption of glutathione, thereby enhancing the chemodynamic therapy (CDT) efficacy. Based on the combined chemotherapy and CDT, the treatment with this system leads to superior antitumor outcome. | URI: | https://hdl.handle.net/10356/156675 | ISSN: | 1936-0851 | DOI: | 10.1021/acsnano.1c08536 | Schools: | School of Physical and Mathematical Sciences | Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.1c08536. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SPMS Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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Manuscript.pdf | 24.83 MB | Adobe PDF | View/Open |
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