Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156675
Title: Albumin-based therapeutics capable of glutathione consumption and hydrogen peroxide generation for synergetic chemodynamic and chemotherapy of cancer
Authors: Yang, Guangbao
Wang, Dongdong
Phua, Fiona Soo Zeng
Bindra, Anivind Kaur
Qian, Cheng
Zheng, Rui
Cheng, Liang
Liu, Guofeng
Wu, Hongwei
Liu, Zhuang
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Yang, G., Wang, D., Phua, F. S. Z., Bindra, A. K., Qian, C., Zheng, R., Cheng, L., Liu, G., Wu, H., Liu, Z. & Zhao, Y. (2022). Albumin-based therapeutics capable of glutathione consumption and hydrogen peroxide generation for synergetic chemodynamic and chemotherapy of cancer. ACS Nano, 16(2), 2319-2329. https://dx.doi.org/10.1021/acsnano.1c08536
Project: A20E5c0081
NRF-NRFI2018-03
Journal: ACS Nano
Abstract: A nanoscale therapeutic system with good biocompatibility was facilely fabricated by the coassembly of human serum albumin and glucose oxidase (GOD), where the former was pretreated with metal ions through a chelating agent or the chemotherapeutic prodrug oxaliplatin (Oxa(IV)). Among different chelating metal ions used, Mn2+ ion was selected to produce hydroxyl radical (•OH) efficiently through Fenton-like reaction, while GOD loaded in the system was able to generate a large amount of hydrogen peroxide for promoting efficient conversion into highly toxic •OH. In the meanwhile, the conversion of the Oxa(IV) prodrug into chemotherapeutic Oxa(II) was beneficial for the consumption of glutathione, thereby enhancing the chemodynamic therapy (CDT) efficacy. Based on the combined chemotherapy and CDT, the treatment with this system leads to superior antitumor outcome.
URI: https://hdl.handle.net/10356/156675
ISSN: 1936-0851
DOI: 10.1021/acsnano.1c08536
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.1c08536.
Fulltext Permission: embargo_20230228
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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  Until 2023-02-28
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