Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156809
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dc.contributor.authorTian, Boshien_US
dc.contributor.authorLiu, Shikaien_US
dc.contributor.authorFeng, Lilien_US
dc.contributor.authorLiu, Shaohuaen_US
dc.contributor.authorGai, Shilien_US
dc.contributor.authorDai, Yunluen_US
dc.contributor.authorXie, Lisien_US
dc.contributor.authorLiu, Binen_US
dc.contributor.authorYang, Piaopingen_US
dc.contributor.authorZhao, Yanlien_US
dc.date.accessioned2022-04-25T08:56:08Z-
dc.date.available2022-04-25T08:56:08Z-
dc.date.issued2021-
dc.identifier.citationTian, B., Liu, S., Feng, L., Liu, S., Gai, S., Dai, Y., Xie, L., Liu, B., Yang, P. & Zhao, Y. (2021). Renal-clearable nickel-doped carbon dots with boosted photothermal conversion efficiency for multimodal imaging-guided cancer therapy in the second near-infrared biowindow. Advanced Functional Materials, 31(26), 2100549-. https://dx.doi.org/10.1002/adfm.202100549en_US
dc.identifier.issn1616-301Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/156809-
dc.description.abstractPhotothermal agents with absorption in the second near-infrared (NIR-II) biowindow have attracted increasing attention for photothermal therapy (PTT) on account of their deeper tissue penetration capacity. However, most of the current NIR-II photothermal agents exhibit low photothermal conversion efficiency (PCE) and long-term biotoxicity. To overcome these shortcomings, herein, nickel and nitrogen co-doped carbon dots (Ni-CDs, ≈4.6 nm) are prepared via a facile one-pot hydrothermal approach for imaging-guided PTT in the NIR-II window. The Ni-CDs exhibit significant absorption in the NIR-II region with a distinguished PCE as high as 76.1% (1064 nm) and have excellent photostability and biocompatibility. Furthermore, the Ni-CDs can be employed as photothermal, photoacoustic, and magnetic resonance imaging contrast agents because of their outstanding photothermal effect and instinctive paramagnetic feature. The Ni-CDs demonstrate significant PTT efficacy of tumor upon 1064 nm irradiation with a low power density (0.5 W cm−2). The Ni-CDs can be eliminated from the body via a renal filtration pathway, thereby minimizing their long-term biotoxicity. Therefore, this work provides a simple and feasible approach to develop photothermal agents with remarkable PCE in the NIR-II region, presenting good biosafety for multimodal imaging-guided PTT of tumor.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.language.isoenen_US
dc.relationA20E5c0081en_US
dc.relation.ispartofAdvanced Functional Materialsen_US
dc.rightsThis is the peer reviewed version of the following article: Tian, B., Liu, S., Feng, L., Liu, S., Gai, S., Dai, Y., Xie, L., Liu, B., Yang, P. & Zhao, Y. (2021). Renal-clearable nickel-doped carbon dots with boosted photothermal conversion efficiency for multimodal imaging-guided cancer therapy in the second near-infrared biowindow. Advanced Functional Materials, 31(26), 2100549-, which has been published in final form at https://doi.org/10.1002/adfm.202100549. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectScience::Chemistryen_US
dc.titleRenal-clearable nickel-doped carbon dots with boosted photothermal conversion efficiency for multimodal imaging-guided cancer therapy in the second near-infrared biowindowen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1002/adfm.202100549-
dc.description.versionSubmitted/Accepted versionen_US
dc.identifier.issue26en_US
dc.identifier.volume31en_US
dc.identifier.spage2100549en_US
dc.subject.keywordsMultimodal Imagingen_US
dc.subject.keywordsNickel-Doped Carbon Dotsen_US
dc.description.acknowledgementThis work was supported by the National Natural Science Foundation of China (51972075, 51772059, and 21601213), the Natural Science Foundation of Heilongjiang Province (YQ2019E014), and the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081).en_US
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