Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156809
Title: Renal-clearable nickel-doped carbon dots with boosted photothermal conversion efficiency for multimodal imaging-guided cancer therapy in the second near-infrared biowindow
Authors: Tian, Boshi
Liu, Shikai
Feng, Lili
Liu, Shaohua
Gai, Shili
Dai, Yunlu
Xie, Lisi
Liu, Bin
Yang, Piaoping
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2021
Source: Tian, B., Liu, S., Feng, L., Liu, S., Gai, S., Dai, Y., Xie, L., Liu, B., Yang, P. & Zhao, Y. (2021). Renal-clearable nickel-doped carbon dots with boosted photothermal conversion efficiency for multimodal imaging-guided cancer therapy in the second near-infrared biowindow. Advanced Functional Materials, 31(26), 2100549-. https://dx.doi.org/10.1002/adfm.202100549
Project: A20E5c0081
Journal: Advanced Functional Materials 
Abstract: Photothermal agents with absorption in the second near-infrared (NIR-II) biowindow have attracted increasing attention for photothermal therapy (PTT) on account of their deeper tissue penetration capacity. However, most of the current NIR-II photothermal agents exhibit low photothermal conversion efficiency (PCE) and long-term biotoxicity. To overcome these shortcomings, herein, nickel and nitrogen co-doped carbon dots (Ni-CDs, ≈4.6 nm) are prepared via a facile one-pot hydrothermal approach for imaging-guided PTT in the NIR-II window. The Ni-CDs exhibit significant absorption in the NIR-II region with a distinguished PCE as high as 76.1% (1064 nm) and have excellent photostability and biocompatibility. Furthermore, the Ni-CDs can be employed as photothermal, photoacoustic, and magnetic resonance imaging contrast agents because of their outstanding photothermal effect and instinctive paramagnetic feature. The Ni-CDs demonstrate significant PTT efficacy of tumor upon 1064 nm irradiation with a low power density (0.5 W cm−2). The Ni-CDs can be eliminated from the body via a renal filtration pathway, thereby minimizing their long-term biotoxicity. Therefore, this work provides a simple and feasible approach to develop photothermal agents with remarkable PCE in the NIR-II region, presenting good biosafety for multimodal imaging-guided PTT of tumor.
URI: https://hdl.handle.net/10356/156809
ISSN: 1616-301X
DOI: 10.1002/adfm.202100549
Rights: This is the peer reviewed version of the following article: Tian, B., Liu, S., Feng, L., Liu, S., Gai, S., Dai, Y., Xie, L., Liu, B., Yang, P. & Zhao, Y. (2021). Renal-clearable nickel-doped carbon dots with boosted photothermal conversion efficiency for multimodal imaging-guided cancer therapy in the second near-infrared biowindow. Advanced Functional Materials, 31(26), 2100549-, which has been published in final form at https://doi.org/10.1002/adfm.202100549. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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