Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156869
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dc.contributor.authorKong, Jian Huaen_US
dc.date.accessioned2022-04-27T05:13:16Z-
dc.date.available2022-04-27T05:13:16Z-
dc.date.issued2022-
dc.identifier.citationKong, J. H. (2022). Chaperone-mediated formation of shell-like TDP-43 condensates. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/156869en_US
dc.identifier.urihttps://hdl.handle.net/10356/156869-
dc.description.abstractTransactivation response element DNA binding protein 43 (TDP-43), an RNA-binding protein is the major component of inclusion bodies in patients afflicted with Amyotrophic Lateral Sclerosis (ALS). A recent study established that a compromise in RNA-binding capacity of TDP-43, resulting from post-translational modifications or ALS-causing mutations, confers TDP-43 the ability to de-mix into intranuclear liquid spherical shells with a liquid core. The major chaperone, Heat shock protein 70 (Hsp70), was reported to be enriched within the liquid core and pivotal in maintenance of the shell structure. To examine the presence of other chaperones in the core of the TDP-43 shell. Interestingly, reduced function of the Hsp70 system abrogated the shell formation. It is very likely that other chaperones are also enriched in the TDP-43 shell-like structures. Further investigation into how chaperones mediate TDP-43 phase separation could illuminate the molecular basis for ALS.en_US
dc.language.isoenen_US
dc.publisherNanyang Technological Universityen_US
dc.subjectScience::Biological sciences::Molecular biologyen_US
dc.titleChaperone-mediated formation of shell-like TDP-43 condensatesen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorChoe Young Junen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degreeBachelor of Science in Biological Sciencesen_US
dc.contributor.supervisoremailyjchoe@ntu.edu.sgen_US
item.grantfulltextembargo_restricted_20240425-
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Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)
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