Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/156967
Title: Thin film composite hollow fibre membrane for pharmaceutical concentration and solvent recovery
Authors: Goh, Keng Siang
Chen, Yunfeng
Chong, Jeng Yi
Bae, Tae-Hyun
Wang, Rong
Keywords: Engineering::Civil engineering
Issue Date: 2021
Source: Goh, K. S., Chen, Y., Chong, J. Y., Bae, T. & Wang, R. (2021). Thin film composite hollow fibre membrane for pharmaceutical concentration and solvent recovery. Journal of Membrane Science, 621, 119008-. https://dx.doi.org/10.1016/j.memsci.2020.119008
Journal: Journal of Membrane Science 
Abstract: A 100-piece hollow fibre thin-film composite membrane module was successfully developed for pharmaceutical concentration and solvent recovery. To increase its packing density, thinner P84 polyimide hollow fibre substrates were spun using a smaller spinneret. The substrates were subsequently cross-linked with hexamethylene diamine to achieve organic solvent resistance. An MPD-based thin-film composite was synthesized through interfacial polymerisation to increase selectivity for solutes of less than 300 Da. The thin-film composite was then solvent-activated using N,N-dimethylformamide to increase its solvent permeability. The resulting membrane exhibited excellent performance with 24.2 l m−2 h−1 bar−1 acetone permeability and 90.1% methyl red (269 Da) rejection. In addition, the solvent-activated membrane maintained its performance for prolonged period, demonstrating the scalability of the thin-film composite fabrication process and stability of solvent-activated membranes. The membrane was also able to concentrate levofloxacin (361 Da) from 500 ppm to 20,000 ppm in acetone using a batch process, showing promising results for pharmaceutical applications.
URI: https://hdl.handle.net/10356/156967
ISSN: 0376-7388
DOI: 10.1016/j.memsci.2020.119008
Rights: © 2020 Elsevier B.V. All rights reserved. This paper was published in Journal of Membrane Science and is made available with permission of Elsevier B.V.
Fulltext Permission: embargo_20230308
Fulltext Availability: With Fulltext
Appears in Collections:CEE Journal Articles
NEWRI Journal Articles

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