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dc.contributor.authorGoh, Keng Siangen_US
dc.contributor.authorChen, Yunfengen_US
dc.contributor.authorNg, Daniel Yee Fanen_US
dc.contributor.authorChew, Jia Weien_US
dc.contributor.authorWang, Rongen_US
dc.identifier.citationGoh, K. S., Chen, Y., Ng, D. Y. F., Chew, J. W. & Wang, R. (2022). Organic solvent forward osmosis membranes for pharmaceutical concentration. Journal of Membrane Science, 642, 119965-.
dc.description.abstractA scaled-up hollow fibre thin-film composite (TFC) module was successfully developed for organic solvent forward osmosis (OSFO) application in the pharmaceutical industry. The membrane consists of cross-linked P84 polyimide substrate with a polyamide selective layer, formed via interfacial polymerisation. The performance of the lab-scale module was compared to the scaled-up module in reverse osmosis and forward osmosis modes. The results from both tests revealed that the solvent permeability of the scaled-up module decreased while its selectivity increased slightly. This might be caused by the uneven distribution of liquids during interfacial polymerisation, leading to varied membrane performance. The scaled-up module was further tested for OSFO performance using a range of PEG-400 concentrations (0.5–2 M) in acetone and isopropanol as draw solutions. At 2 M PEG-400 concentration, the module demonstrated high isopropanol and acetone permeability of 0.63 LMH and 13.9 LMH, respectively. Moreover, the reverse solute flux of PEG-400 in acetone and isopropanol were relatively low at 0.188 g/l and 0.153 g/l, respectively. The module was further tested for OSFO application in the pharmaceutical industry by concentrating levofloxacin in acetone, using 2 M PEG-400 as draw solution. The process was able to concentrate levofloxacin from 1000 ppm to 16,000 ppm with very low reverse solute flux of 0.178 g/l. Therefore, this work presents a scalable TFC membrane for OSFO application in the pharmaceutical industry.en_US
dc.description.sponsorshipEconomic Development Board (EDB)en_US
dc.relation.ispartofJournal of Membrane Scienceen_US
dc.rights© 2021 Elsevier B.V. All rights reserved. This paper was published in Journal of Membrane Science and is made available with permission of Elsevier B.V.en_US
dc.subjectEngineering::Civil engineeringen_US
dc.titleOrganic solvent forward osmosis membranes for pharmaceutical concentrationen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Civil and Environmental Engineeringen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.researchNanyang Environment and Water Research Instituteen_US
dc.contributor.researchSingapore Membrane Technology Centreen_US
dc.description.versionSubmitted/Accepted versionen_US
dc.subject.keywordsOrganic Solvent Forward Osmosisen_US
dc.subject.keywordsScaled-Up Moduleen_US
dc.description.acknowledgementThe authors acknowledge Economic Development Board (EDB) of Singapore for funding the Singapore Membrane Technology Centre (SMTC), Interdisciplinary Graduate Programme, Nanyang Environment and Water Research Institute, Nanyang Technological University.en_US
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