Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/157027
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dc.contributor.authorPeng, Mengjiaoen_US
dc.contributor.authorXiang, Limingen_US
dc.date.accessioned2022-04-30T07:43:21Z-
dc.date.available2022-04-30T07:43:21Z-
dc.date.issued2021-
dc.identifier.citationPeng, M. & Xiang, L. (2021). Correlation-based joint feature screening for semi-competing risks outcomes with application to breast cancer data. Statistical Methods in Medical Research, 30(11), 2428-2446. https://dx.doi.org/10.1177/09622802211037071en_US
dc.identifier.issn0962-2802en_US
dc.identifier.urihttps://hdl.handle.net/10356/157027-
dc.description.abstractUltrahigh-dimensional gene features are often collected in modern cancer studies in which the number of gene features p is extremely larger than sample size n. While gene expression patterns have been shown to be related to patients' survival in microarray-based gene expression studies, one has to deal with the challenges of ultrahigh-dimensional genetic predictors for survival predicting and genetic understanding of the disease in precision medicine. The problem becomes more complicated when two types of survival endpoints, distant metastasis-free survival and overall survival, are of interest in the study and outcome data can be subject to semi-competing risks due to the fact that distant metastasis-free survival is possibly censored by overall survival but not vice versa. Our focus in this paper is to extract important features, which have great impacts on both distant metastasis-free survival and overall survival jointly, from massive gene expression data in the semi-competing risks setting. We propose a model-free screening method based on the ranking of the correlation between gene features and the joint survival function of two endpoints. The method accounts for the relationship between two endpoints in a simply defined utility measure that is easy to understand and calculate. We show its favorable theoretical properties such as the sure screening and ranking consistency, and evaluate its finite sample performance through extensive simulation studies. Finally, an application to classifying breast cancer data clearly demonstrates the utility of the proposed method in practice.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationRG98/20en_US
dc.relation.ispartofStatistical Methods in Medical Researchen_US
dc.rights© 2021 The Author(s). All rights reserved. This paper was published in Statistical Methods in Medical Research and is made available with permission of The Author(s).en_US
dc.subjectScience::Mathematicsen_US
dc.titleCorrelation-based joint feature screening for semi-competing risks outcomes with application to breast cancer dataen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1177/09622802211037071-
dc.description.versionSubmitted/Accepted versionen_US
dc.identifier.pmid34519231-
dc.identifier.scopus2-s2.0-85114854933-
dc.identifier.issue11en_US
dc.identifier.volume30en_US
dc.identifier.spage2428en_US
dc.identifier.epage2446en_US
dc.subject.keywordsGene Expression Dataen_US
dc.subject.keywordsJoint Survival Functionen_US
dc.description.acknowledgementXiang’s research was supported by the Singapore Ministry of Education Academic Research Fund Tier 1 grant RG98/20 and Peng’s research was supported by National Natural Science Foundation of China (NSFC Grant No. 92046005).en_US
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