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Title: A modular approach to enzymatic ligation of peptides and proteins with oligonucleotides
Authors: Tan, Derrick Jing Yang
Cheong, Vee Vee
Lim, Kah Wai
Phan, Anh Tuân
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Tan, D. J. Y., Cheong, V. V., Lim, K. W. & Phan, A. T. (2021). A modular approach to enzymatic ligation of peptides and proteins with oligonucleotides. Chemical Communications, 57(45), 5507-5510.
Project: NRF-NRFI2017-09
Journal: Chemical Communications
Abstract: Joining peptides and oligonucleotides offers potential benefits, but current methods remain laborious. Here we present a novel approach towards enzymatic ligation of the two modalities through the development of tag phosphoramidites that readily couple onto oligonucleotides. This simple and highly efficient approach paves the way towards streamlined development and production of peptide/protein-oligonucleotide conjugates.
ISSN: 1359-7345
DOI: 10.1039/d1cc01348c
Schools: School of Physical and Mathematical Sciences 
Research Centres: NTU Institute of Structural Biology 
Rights: © 2021 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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