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Title: G4-PROTAC: targeted degradation of a G-quadruplex binding protein
Authors: Patil, Kiran M.
Chin, Danielle
Seah, Hui Ling
Shi, Qi
Lim, Kah Wai
Phan, Anh Tuân
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Patil, K. M., Chin, D., Seah, H. L., Shi, Q., Lim, K. W. & Phan, A. T. (2021). G4-PROTAC: targeted degradation of a G-quadruplex binding protein. Chemical Communications, 57(95), 12816-12819.
Project: MOE2018-T2-2- 029
Journal: Chemical Communications 
Abstract: G-quadruplex (G4)-binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides a new way to explore G4-protein networks and to develop potential therapeutics.
ISSN: 1359-7345
DOI: 10.1039/d1cc05025g
Schools: School of Physical and Mathematical Sciences 
Research Centres: NTU Institute of Structural Biology 
Rights: © 2021 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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