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https://hdl.handle.net/10356/158329| Title: | G4-PROTAC: targeted degradation of a G-quadruplex binding protein | Authors: | Patil, Kiran M. Chin, Danielle Seah, Hui Ling Shi, Qi Lim, Kah Wai Phan, Anh Tuân |
Keywords: | Science::Biological sciences Science::Chemistry |
Issue Date: | 2021 | Source: | Patil, K. M., Chin, D., Seah, H. L., Shi, Q., Lim, K. W. & Phan, A. T. (2021). G4-PROTAC: targeted degradation of a G-quadruplex binding protein. Chemical Communications, 57(95), 12816-12819. https://dx.doi.org/10.1039/d1cc05025g | Project: | MOE2018-T2-2- 029 | Journal: | Chemical Communications | Abstract: | G-quadruplex (G4)-binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides a new way to explore G4-protein networks and to develop potential therapeutics. | URI: | https://hdl.handle.net/10356/158329 | ISSN: | 1359-7345 | DOI: | 10.1039/d1cc05025g | Schools: | School of Physical and Mathematical Sciences | Research Centres: | NTU Institute of Structural Biology | Rights: | © 2021 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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| text_clean.pdf | 426.21 kB | Adobe PDF |  View/Open |
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