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Title: Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces
Authors: Singh, Juhi
Steele, Terry W. J.
Lim, Sierin
Keywords: Science::Medicine::Tissue engineering
Issue Date: 2022
Source: Singh, J., Steele, T. W. J. & Lim, S. (2022). Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces. Journal of Materials Chemistry B, 10(14), 2570-2583.
Project: H19/01/a0/0II9 
Journal: Journal of Materials Chemistry B 
Abstract: Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility. To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces. The aqueous composites crosslink upon photocuring within a minute and exhibit a transition from viscous to elastic adhesive hydrogels. The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues. The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film). The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.
ISSN: 2050-750X
DOI: 10.1039/d1tb02044g
Schools: School of Materials Science and Engineering 
Interdisciplinary Graduate School (IGS) 
School of Chemical and Biomedical Engineering 
Research Centres: NTU Institute for Health Technologies 
Rights: © 2022 The Royal Society of Chemistry. All rights reserved. This paper was published in Journal of Materials Chemistry B and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles
MSE Journal Articles
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