Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/159288
Title: Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation
Authors: Chen, Qi
Nair, Sajith
Ruedl, Christiane
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Chen, Q., Nair, S. & Ruedl, C. (2022). Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation. Life Science Alliance, 5(1), e202101178-. https://dx.doi.org/10.26508/lsa.202101178
Journal: Life Science Alliance
Abstract: The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbiome density along the gastrointestinal tract defines the persistence of ontogenically diverse macrophages, with the highest numbers of the long-lived F4/80hiTim4+ macrophage subset in the less densely colonized small intestine. Furthermore, the microbiome contributes to a tightly regulated monocyte-dependent replenishment of both long- and short-lived F4/80hi macrophages under homeostatic and inflammatory conditions. In the latter situation, the commensals regulate rapid replenishment of the depleted macrophage niche caused by the intestinal inflammation. The microbial ecosystem imprints a favorable cytokine microenvironment in the intestine to support macrophage survival and monocyte-dependent replenishment. Therefore, the host immune system-commensal cross-talk provides an efficient strategy to assure intestinal homeostasis.
URI: https://hdl.handle.net/10356/159288
ISSN: 2575-1077
DOI: 10.26508/lsa.202101178
DOI (Related Dataset): 10.21979/N9/XBXJPP
Rights: © 2021 Chen et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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