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|Title:||Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation||Authors:||Chen, Qi
|Keywords:||Science::Biological sciences||Issue Date:||2022||Source:||Chen, Q., Nair, S. & Ruedl, C. (2022). Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation. Life Science Alliance, 5(1), e202101178-. https://dx.doi.org/10.26508/lsa.202101178||Journal:||Life Science Alliance||Abstract:||The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbiome density along the gastrointestinal tract defines the persistence of ontogenically diverse macrophages, with the highest numbers of the long-lived F4/80hiTim4+ macrophage subset in the less densely colonized small intestine. Furthermore, the microbiome contributes to a tightly regulated monocyte-dependent replenishment of both long- and short-lived F4/80hi macrophages under homeostatic and inflammatory conditions. In the latter situation, the commensals regulate rapid replenishment of the depleted macrophage niche caused by the intestinal inflammation. The microbial ecosystem imprints a favorable cytokine microenvironment in the intestine to support macrophage survival and monocyte-dependent replenishment. Therefore, the host immune system-commensal cross-talk provides an efficient strategy to assure intestinal homeostasis.||URI:||https://hdl.handle.net/10356/159288||ISSN:||2575-1077||DOI:||10.26508/lsa.202101178||DOI (Related Dataset):||10.21979/N9/XBXJPP||Rights:||© 2021 Chen et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SBS Journal Articles|
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Updated on Jun 25, 2022
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