Please use this identifier to cite or link to this item:
Title: Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study
Authors: Tan, Xiao Wei
Lee, Eng Sing
Toh, Matthias Paul Han Sim
Lum, Alvin Wai Mun
Seah, Darren Ee Jin
Leong, Khai Pang
Chan, Christopher Yi Wen
Fung, Daniel Shuen Sheng
Tor, Phern Chern
Keywords: Science::Medicine
Issue Date: 2021
Source: Tan, X. W., Lee, E. S., Toh, M. P. H. S., Lum, A. W. M., Seah, D. E. J., Leong, K. P., Chan, C. Y. W., Fung, D. S. S. & Tor, P. C. (2021). Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study. Journal of Psychiatric Research, 142, 48-53.
Journal: Journal of Psychiatric Research
Abstract: Aim: To compare the risk of death, the prevalence of comorbid chronic physical illness and mortality among an Asian population of patients with mental disorders. Methods: This was a retrospective data analysing of medical records of patients with schizophrenia, depression, anxiety, bipolar disorder, alcohol use disorder (AUD) or substance use disorder and the comorbid chronic physical illnesses. The hazard risk of death was calculated with Cox regression and compared between patients with and without comorbid chronic physical illness(es). Odds ratios of specific comorbid chronic physical illness were calculated with logistic regression and mean crude death rate was calculated for patients with different mental disorders. Results: A total of 56,447 patients with mental disorders were included in the analysis. Compared to patients without comorbid physical illness, patients with mental-physical comorbidity were associated with a higher risk of death [2.36 (2.22–2.52); hazard ratio (95% CI)] and less estimated survival days [2157 (2142–2172) vs 2508 (2504–2513)]. Compared to other mental disorders, those with AUD had the highest prevalence of two or more comorbid chronic physical illnesses and associated with the highest odds of comorbid hypertension, diabetes mellitus, stroke, nephritis, chronic kidney disease, and cancer. The highest one-year crude death rate was similarly observed in patients with AUD. Conclusions: Mental-physical comorbidity was associated with a higher risk of death compared to patients with mental disorders only. The highest prevalence of mental-physical comorbidity and mortality were observed in patients with AUD. More attention and resources may be needed to tackle the burden of AUD.
ISSN: 0022-3956
DOI: 10.1016/j.jpsychires.2021.07.039
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: National Healthcare Group Polyclinics
Institute of Mental Health
Duke-NUS Graduate Medical School
Rights: © 2021 Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

Citations 50

Updated on Dec 3, 2023

Web of ScienceTM
Citations 50

Updated on Oct 27, 2023

Page view(s)

Updated on Dec 8, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.