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Title: Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions
Authors: Lu, Beibei
Bo, Yiyang
Yi, Mingjie
Wang, Zhenyuan
Zhang, Jichuan
Zhu, Zhenye
Zhao, Yanli
Zhang, Jiaheng
Keywords: Science::Chemistry
Issue Date: 2021
Source: Lu, B., Bo, Y., Yi, M., Wang, Z., Zhang, J., Zhu, Z., Zhao, Y. & Zhang, J. (2021). Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions. Advanced Functional Materials, 31(34), 2102794-.
Project: RT12/19
Journal: Advanced Functional Materials
Abstract: The development of hydrophobic drug and protein delivery carriers remains a challenge. To synthesize L-(-)-carnitine-based ionic liquid (IL), this study applies the density functional theory to investigate the hydrogen bonds and van der Waals force that govern L-(-)-carnitine-based IL formation. An ionic liquid-in-oil microemulsion (IL/O ME) is then developed to facilitate the transdermal delivery of proteins and increase the solubility of drugs. IL/O ME is prepared using isopropyl myristate (IPM), Tween 80/Span 20, and L-(-)-carnitine-based IL. The skin permeation studies conducted using mouse skin show that the insulin permeation percentage of the developed IL/O ME is 3.55 folds higher than that of phosphate-buffered saline and 2.91 folds better than that of a hydrophilic L-(-)-carnitine-based IL. In addition, the solubility of two drug molecules, that is, rosiglitazone and bezafibrate, in IL/O ME is at least 49.28 folds higher than their solubility in water or IPM. Therefore, IL/O ME can significantly improve the solubility of drugs and increase the permeability of proteins (e.g., insulin), thus demonstrating a promising potential as a delivery carrier.
ISSN: 1616-301X
DOI: 10.1002/adfm.202102794
Schools: School of Physical and Mathematical Sciences 
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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