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Title: Supported lipid bilayer formation: beyond vesicle fusion
Authors: Jackman, Joshua A.
Cho, Nam-Joon
Keywords: Engineering::Materials
Issue Date: 2020
Source: Jackman, J. A. & Cho, N. (2020). Supported lipid bilayer formation: beyond vesicle fusion. Langmuir, 36(6), 1387-1400.
Project: NRF2015NRF-POC0001-19
Journal: Langmuir
Abstract: Supported lipid bilayers (SLBs) are cell-membrane-mimicking platforms that can be formed on solid surfaces and integrated with a wide range of surface-sensitive measurement techniques. SLBs are useful for unravelling details of fundamental membrane biology and biophysics as well as for various medical, biotechnology, and environmental science applications. Thus, there is high interest in developing simple and robust methods to fabricate SLBs. Currently, vesicle fusion is a popular method to form SLBs and involves the adsorption and spontaneous rupture of lipid vesicles on a solid surface. However, successful vesicle fusion depends on high-quality vesicle preparation, and it typically works with a narrow range of material supports and lipid compositions. In this Feature Article, we summarize current progress in developing two new SLB fabrication techniques termed the solvent-assisted lipid bilayer (SALB) and bicelle methods, which have compelling advantages such as simple sample preparation and compatibility with a wide range of material supports and lipid compositions. The molecular self-assembly principles underpinning the two strategies and important experimental parameters are critically discussed, and recent application examples are presented. Looking forward, we envision that these emerging SLB fabrication strategies can be widely adopted by specialists and nonspecialists alike, paving the way to enriching our understanding of lipid membrane properties and realizing new application possibilities.
ISSN: 0743-7463
DOI: 10.1021/acs.langmuir.9b03706
Schools: School of Materials Science and Engineering 
Rights: © 2020 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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