Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/159768
Title: Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase
Authors: Koh, Wei Xiang
Coppo, Lucia
Ganguly, Rakesh
Holmgren, Arne
Leong, Weng Kee
Keywords: Science::Chemistry
Issue Date: 2021
Source: Koh, W. X., Coppo, L., Ganguly, R., Holmgren, A. & Leong, W. K. (2021). Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase. Journal of Organometallic Chemistry, 943, 121822-. https://dx.doi.org/10.1016/j.jorganchem.2021.121822
Project: RG121/18
Journal: Journal of Organometallic Chemistry
Abstract: Ferrocenyl and ruthenocenyl derivatives of ebselen are found to be competitive inhibitors of mammalian TrxR, with IC50 of 4.2 ± 0.3 and 2.5 ± 0.3 µM, respectively. The inhibition of TrxR is selective over GR, and in the presence of excess GSH. They exhibit lower Km values than ebselen and the natural substrate, Trx.
URI: https://hdl.handle.net/10356/159768
ISSN: 0022-328X
DOI: 10.1016/j.jorganchem.2021.121822
Schools: School of Physical and Mathematical Sciences 
Rights: © 2021 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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