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https://hdl.handle.net/10356/159768| Title: | Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase | Authors: | Koh, Wei Xiang Coppo, Lucia Ganguly, Rakesh Holmgren, Arne Leong, Weng Kee |
Keywords: | Science::Chemistry | Issue Date: | 2021 | Source: | Koh, W. X., Coppo, L., Ganguly, R., Holmgren, A. & Leong, W. K. (2021). Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase. Journal of Organometallic Chemistry, 943, 121822-. https://dx.doi.org/10.1016/j.jorganchem.2021.121822 | Project: | RG121/18 | Journal: | Journal of Organometallic Chemistry | Abstract: | Ferrocenyl and ruthenocenyl derivatives of ebselen are found to be competitive inhibitors of mammalian TrxR, with IC50 of 4.2 ± 0.3 and 2.5 ± 0.3 µM, respectively. The inhibition of TrxR is selective over GR, and in the presence of excess GSH. They exhibit lower Km values than ebselen and the natural substrate, Trx. | URI: | https://hdl.handle.net/10356/159768 | ISSN: | 0022-328X | DOI: | 10.1016/j.jorganchem.2021.121822 | Schools: | School of Physical and Mathematical Sciences | Rights: | © 2021 Elsevier B.V. All rights reserved. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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