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https://hdl.handle.net/10356/159784
Title: | Activation of autophagy ameliorates age-related neurogenesis decline and neurodysfunction in adult mice | Authors: | Yang, Na Liu, Xueqin Niu, Xiaojie Wang, Xiaoqiang Jiang, Rong Yuan, Na Wang, Jianrong Zhang, Chengwu Lim, Kah-Leong Lu, Li |
Keywords: | Science::Medicine | Issue Date: | 2022 | Source: | Yang, N., Liu, X., Niu, X., Wang, X., Jiang, R., Yuan, N., Wang, J., Zhang, C., Lim, K. & Lu, L. (2022). Activation of autophagy ameliorates age-related neurogenesis decline and neurodysfunction in adult mice. Stem Cell Reviews and Reports, 18(2), 626-641. https://dx.doi.org/10.1007/s12015-021-10265-0 | Journal: | Stem Cell Reviews and Reports | Abstract: | Adult neurogenesis is the ongoing generation of functional new neurons from neural progenitor cells (NPCs) in the mammalian brain. However, this process declines with aging, which is implicated in the recession of brain function and neurodegeneration. Understanding the mechanism of adult neurogenesis and stimulating neurogenesis will benefit the mitigation of neurodegenerative diseases. Autophagy, a highly conserved process of cellular degradation, is essential for maintaining cellular homeostasis and normal function. Whether and how autophagy affects adult neurogenesis remains poorly understood. In present study, we revealed a close connection between impaired autophagy and adult neurogenetic decline. Expression of autophagy-related genes and autophagic activity were significantly declined in the middle-adult subventricular/subgranular zone (SVZ/SGZ) homogenates and cultured NPCs, and inhibiting autophagy by siRNA interference resulted in impaired proliferation and differentiation of NPCs. Conversely, stimulating autophagy by rapamycin not only revitalized the viability of middle-adult NPCs, but also facilitated the neurogenesis in middle-adult SVZ/SGZ. More importantly, autophagic activation by rapamycin also ameliorated the olfactory sensitivity and cognitional capacities in middle-adult mice. Taken together, our results reveal that compromised autophagy is involved in the decline of adult neurogenesis, which could be reversed by autophagy activation. It also shed light on the regulation of adult neurogenesis and paves the way for developing a therapeutic strategy for aging and neurodegenerative diseases. | URI: | https://hdl.handle.net/10356/159784 | ISSN: | 2629-3269 | DOI: | 10.1007/s12015-021-10265-0 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © 2021 The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. All rights reserved. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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