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dc.contributor.authorShi, Yuzhien_US
dc.contributor.authorNguyen, Kim Trucen_US
dc.contributor.authorChin, Lip Keten_US
dc.contributor.authorLi, Zhenyuen_US
dc.contributor.authorXiao, Liminen_US
dc.contributor.authorCai, Hongen_US
dc.contributor.authorYu, Ruozhenen_US
dc.contributor.authorHuang, Weien_US
dc.contributor.authorFeng, Shilunen_US
dc.contributor.authorYap, Peng Huaten_US
dc.contributor.authorLiu, Jingquanen_US
dc.contributor.authorZhang, Yien_US
dc.contributor.authorLiu, Ai Qunen_US
dc.identifier.citationShi, Y., Nguyen, K. T., Chin, L. K., Li, Z., Xiao, L., Cai, H., Yu, R., Huang, W., Feng, S., Yap, P. H., Liu, J., Zhang, Y. & Liu, A. Q. (2021). Trapping and detection of single viruses in an optofluidic chip. ACS Sensors, 6(9), 3445-3450.
dc.description.abstractAccurate single virus detection is critical for disease diagnosis and early prevention, especially in view of current pandemics. Numerous detection methods have been proposed with the single virus sensitivity, including the optical approaches and immunoassays. However, few of them hitherto have the capability of both trapping and detection of single viruses in the microchannel. Here, we report an optofluidic potential well array to trap nanoparticles stably in the flow stream. The nanoparticle is bound with single viruses and fluorescence quantum dots through an immunolabeling protocol. Single viruses can be swiftly captured in the microchannel by optical forces and imaged by a camera. The number of viruses in solution and on each particle can be quantified via image processing. Our method can trap and detect single viruses in the 1 mL serum or water in 2 h, paving an avenue for the advanced, fast, and accurate clinical diagnosis, as well as the study of virus infectivity, mutation, drug inhibition, etc.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relation.ispartofACS Sensorsen_US
dc.rights© 2021 American Chemical Society. All rights reserved.en_US
dc.subjectEngineering::Electrical and electronic engineeringen_US
dc.titleTrapping and detection of single viruses in an optofluidic chipen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.subject.keywordsOptical Trappingen_US
dc.subject.keywordsSingle Virus Detectionen_US
dc.description.acknowledgementThis work was supported by the Singapore National Research Foundation under the Competitive Research Program (NRFCRP13-2014-01), and the Singapore Ministry of Education (MOE) Tier 3 grant (MOE2017-T3-1-001).en_US
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