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Title: Prefrontal-hippocampus plasticity reinstated by an enriched environment during stress
Authors: Wu, You
Mitra, Rupshi
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Wu, Y. & Mitra, R. (2021). Prefrontal-hippocampus plasticity reinstated by an enriched environment during stress. Neuroscience Research, 170, 360-363.
Project: RG 46/12
Journal: Neuroscience Research
Abstract: Chronic stress causes dendritic atrophy of neurons within the hippocampus and medial prefrontal cortex. In this report, we show that chronic stress leads to reduced long-term potentiation in the pathway from the hippocampus to the medial prefrontal cortex of rats; and that such reduction is rescued by enriched housing environment. Connectivity between the hippocampus and medial prefrontal cortex is proposed to be an essential substrate that is often compromised in several psychiatric disorders. Our observations suggest that a short period of complexity in the housing environment has the potential to protect the functional integrity of this important connection.
ISSN: 0168-0102
DOI: 10.1016/j.neures.2020.07.004
Schools: School of Biological Sciences 
Rights: © 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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