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https://hdl.handle.net/10356/159979
Title: | Copper-catalyzed meta-selective arylation of phenol derivatives: an easy access to m-aryl phenols | Authors: | Maraswami, Manikantha Hirao, Hajime Loh, Teck-Peng |
Keywords: | Science::Chemistry | Issue Date: | 2021 | Source: | Maraswami, M., Hirao, H. & Loh, T. (2021). Copper-catalyzed meta-selective arylation of phenol derivatives: an easy access to m-aryl phenols. ACS Catalysis, 11(4), 2302-2309. https://dx.doi.org/10.1021/acscatal.0c05481 | Project: | M4012045.110 (RG12/18-S) | Journal: | ACS Catalysis | Abstract: | Achieving selective meta-functionalization of phenols is a significant challenge. Accessing such compounds generally needs elevated temperature or incorporation of complex templates. Here, we report a general approach to achieve meta-arylated phenols with a simple and common directing group. This coppercatalyzed protocol proceeds with complete meta-selectivity and tolerates a variety of functional groups in both coupling partners. Computational studies have revealed that the reaction proceeded via a Heck-like pathway. | URI: | https://hdl.handle.net/10356/159979 | ISSN: | 2155-5435 | DOI: | 10.1021/acscatal.0c05481 | Schools: | School of Physical and Mathematical Sciences | Rights: | © 2021 American Chemical Society. All rights reserved. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SPMS Journal Articles |
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