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Title: Copper-catalyzed meta-selective arylation of phenol derivatives: an easy access to m-aryl phenols
Authors: Maraswami, Manikantha
Hirao, Hajime
Loh, Teck-Peng
Keywords: Science::Chemistry
Issue Date: 2021
Source: Maraswami, M., Hirao, H. & Loh, T. (2021). Copper-catalyzed meta-selective arylation of phenol derivatives: an easy access to m-aryl phenols. ACS Catalysis, 11(4), 2302-2309.
Project: M4012045.110 (RG12/18-S)
Journal: ACS Catalysis
Abstract: Achieving selective meta-functionalization of phenols is a significant challenge. Accessing such compounds generally needs elevated temperature or incorporation of complex templates. Here, we report a general approach to achieve meta-arylated phenols with a simple and common directing group. This coppercatalyzed protocol proceeds with complete meta-selectivity and tolerates a variety of functional groups in both coupling partners. Computational studies have revealed that the reaction proceeded via a Heck-like pathway.
ISSN: 2155-5435
DOI: 10.1021/acscatal.0c05481
Schools: School of Physical and Mathematical Sciences 
Rights: © 2021 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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